Rotation Prep

Published June 17, 2022

A brief refresher with useful tables, figures, and research summaries

Substance Use Disorders

According to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria, a substance use disorder refers to substance use that causes significant problems, including health, disability, and behavioral symptoms that affect an individual’s life. Substance use disorders are classified as mild, moderate, or severe, depending on how many of the diagnostic criteria are met.

In this section, we review the following topics:

Diagnostic Criteria for Substance Use Disorder

The DSM-5 criteria for diagnosis of a substance use disorder are listed in the following table.

DSM-5 Diagnostic Criteria for Substance-Use Disorder
  • Substance is taken in greater amount than intended.

  • There is persistent desire or unsuccessful effort to cut down or control use.

  • There is excessive time spent to obtain, use, or recover from the substance.

  • There is craving for the substance.

  • Repeated use leads to inability to perform role in the workplace or at school or home.

  • Use continues despite negative consequences in social and interpersonal situations.

  • Valued social or work-related roles are stopped because of use.

  • Repeated substance use occurs in potentially dangerous situations.

  • Substance use is not deterred by medical or psychiatric complication.

  • Tolerance develops; an increasing amount is needed to obtain effects.

  • Withdrawal syndrome occurs or patient takes substance to prevent withdrawal.

During the past year, the presence of two to three symptoms is considered mild, the presence of four to five symptoms is moderate, and the presence of six or more symptoms is severe.

Screening for Substance Use Disorders

The Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based method for use in community-based clinics for identification, early intervention, and treatment of substance use, abuse, and dependence on alcohol and illicit drugs.

  • Screening: The SBIRT quickly assesses for at risk behavior, severity of use, and assists in predicting the levels of treatment needed and can be used in a variety of healthcare settings.

  • Brief intervention: SBIRT begins with a short conversation to increase insight and awareness of use, provide feedback and advice, and motivate the patient toward behavior change.

  • Referral to treatment: Once a screen is positive, referral is made for additional treatment and support services.

Alcohol Use Disorder

The estimated prevalence of 12-month alcohol use in the United States based on the DSM-5 classification is 14%. Alcohol use disorders can affect anyone, regardless of social status, age, race, or gender. More than 20% of patients in most medical settings are affected by alcohol use disorders (rates are higher in psychiatric wards, trauma wards, and burn services).


Assessment of the DSM–5 criteria for alcohol use disorder can be achieved by asking patients the following questions. The presence of at least two of these symptoms during the same 12-month period indicates a diagnosis of alcohol use disorder.

Questions to Ask in the Assessment of Alcohol Use Disorder
In the past year, have you:

  • Had times when you ended up drinking more, or longer, than you intended?

  • More than once wanted to cut down or stop drinking, or tried to, but couldn’t?

  • Spent a lot of time drinking? Or being sick or getting over other aftereffects?

  • Wanted a drink so badly you couldn’t think of anything else? (new to DSM–5)

  • Found that drinking — or being sick from drinking — often interfered with taking care of your home or family? Or caused job troubles? Or school problems?

  • Continued to drink even though it was causing trouble with your family or friends?

  • Given up or cut back on activities that were important or interesting to you, or gave you pleasure, in order to drink?

  • More than once gotten into situations while or after drinking that increased your chances of getting hurt (such as driving, swimming, using machinery, walking in a dangerous area, or having unsafe sex)?

  • Continued to drink even though it was making you feel depressed or anxious or adding to another health problem? Or after having had a memory blackout?

  • Had to drink more than you once did to get the effect that you want? Or found that your usual number of drinks had much less effect than before?

  • Found that when the effects of alcohol were wearing off, you had withdrawal symptoms, such as trouble sleeping, shakiness, restlessness, nausea, sweating, a racing heart, or a seizure? Or sensed things that were not there?

The presence of two or three symptoms indicates mild severity, four or five symptoms indicates moderate severity, and six or more symptoms indicates severe alcohol use disorder.

Alcohol Withdrawal

A thorough social history and detailed history of alcohol consumption is important to obtain in the evaluation of alcohol withdrawal; 50% of middle-class people with alcohol use disorders have experienced alcohol withdrawal, and the rates are much higher in the hospitalized and homeless. Fewer than 10% of patients experience seizures during withdrawal. Withdrawal seizures often occur within 36 hours after cessation of alcohol use.

In a systematic review and meta-analysis of hospitalized patients, predictors of severe alcohol withdrawal syndrome (e.g., delirium tremens and/or seizure) included prior episodes of alcohol withdrawal as well as low platelet and serum potassium levels. Death is a serious consequence of alcohol withdrawal syndrome, usually resulting from hyperthermia, cardiac arrhythmias, complications of withdrawal seizures, or concomitant medical disorders.

Diagnostic Criteria

The following table lists criteria for diagnosing alcohol withdrawal:

DSM-5 Diagnostic Criteria for Withdrawal Delirium (Delirium Tremens)
A patient who meets the criteria for both alcohol withdrawal and delirium is considered to have withdrawal delirium.

Criteria for Alcohol Withdrawal
  • Cessation of or reduction in heavy and prolonged use of alcohol

  • At least two of eight possible symptoms after reduced use of alcohol:

    • autonomic hyperactivity

    • hand tremor

    • insomnia

    • nausea or vomiting

    • transient hallucinations or illusions

    • psychomotor agitation

    • anxiety

    • generalized tonic–clonic seizures

Criteria for Delirium
  • Decreased attention and awareness

  • Disturbance in attention, awareness, memory, orientation, language, visuospatial ability, perception, or all of these abilities that is a change from the normal level and fluctuates in severity during the day

  • Disturbances in memory, orientation, language, visuospatial ability, or perception

  • No evidence of coma or other evolving neurocognitive disorders


The Clinical Institute Withdrawal Assessment of Alcohol scale, revised (CIWA-Ar), shown in the following table, can be used to assess presence of alcohol withdrawal and need for medication to prevent seizure:

(Source: Recognition and Management of Withdrawal Delirium [Delirium Tremens]. N Engl J Med 2014.)

Predictors of delirium during alcohol withdrawal:

  • CIWA-Ar scores >15 (especially when accompanied by a systolic blood pressure >150 mm Hg or a pulse rate >100 beats per minute)

  • recent withdrawal seizures

  • prior withdrawal delirium or seizures

  • older age

  • recent misuse of other depressant agents

  • concomitant medical problems, including electrolyte abnormalities (e.g., low levels of potassium, magnesium, or both); low platelet counts; and respiratory, cardiac, or gastrointestinal disease


Major treatment goals of alcohol withdrawal are to:

  • control agitation

  • decrease the risk of seizures

  • decrease risk of injury or death

  • prevent relapse

Benzodiazepines (e.g., diazepam, lorazepam, chlorazepate, chlordiazepoxide) are the mainstay of treatment. No single drug in this class has been shown to be superior to others. Required treatment doses vary widely by patient. Patients who do not respond to high doses (and are intubated) may require additional sedation.

Alternative drugs for withdrawal include phenobarbital, carbamazepine, oxcarbazepine, valproic acid, or gabapentin. Dexmedetomidine can be used as an adjunctive agent to treat delirium.

Note: Patients require high-dose, intravenous thiamine before receiving glucose-containing substances to prevent Wernicke encephalopathy. Be cautious when administering fluids because some patients may also have thiamine- or alcohol-related cardiomyopathies.

The following table describes suggested treatment of alcohol withdrawal:

(Source: Recognition and Management of Withdrawal Delirium [Delirium Tremens]. N Engl J Med 2014.)

Relapse Prevention

Treatment strategies to prevent relapse of alcohol misuse include behavioral interventions and pharmacotherapies.

Behavioral interventions:

  • Cognitive behavior therapy (CBT): CBT involves the use of education, relaxation techniques, and stress management aimed to address individual goals and problem-solving skills. CBT is used in the treatment of a variety of psychiatric disorders, ranging from depression to obsessive compulsive disorder and substance use disorders. This type of therapy is particularly useful in patients who are highly motivated.

  • Behavioral therapies based on conditioning: These forms of psychotherapy apply classical conditioning techniques developed by Ivan Pavlov. In the context of alcohol misuse, patients think about cues that induce craving and are exposed to cues in the absence of drinking and rewarded for their abstinence. The evidence of efficacy for this particular intervention is not as strong as evidence for the efficacy of CBT.

  • Motivational enhancement therapy: This therapy uses patients’ insights to help reduce or abstain from drinking alcohol. The level of evidence for the efficacy of this type of therapy is high and similar to CBT.

  • Twelve-step facilitation: Alcoholics Anonymous (AA) programs encourage a supportive environment, spiritual focus, and a buddy system to encourage abstinence. Although the evidence for this type of intervention is mixed, such programs can be substantially beneficial for many individuals. Other community-based or professionally led group programs that have less of a spiritual focus are also available and can provide significant help.


Medications are underutilized in the treatment of alcohol use disorders. The FDA has approved three oral medications (naltrexone, disulfiram, and acamprosate) and a long-acting injectable formulation of naltrexone for the treatment of alcohol dependence.

The following table describes medications used in the treatment of alcohol use disorder and associated adverse effects and mechanism of action:

(Source: Pharmacotherapy for Adults With Alcohol Use Disorder (AUD) in Outpatient Settings. Agency for Healthcare Research and Quality 2011.)

Opioid Use Disorder

Following a peak in 2012 of more than 250 million opioid prescriptions dispensed in the United States, national opioid prescribing rates have steadily declined to more than 190 million prescriptions in 2017. In 2016, according to the Centers for Disease Control, more than 11.5 million people reported misuse of prescription pain medications in the past year. The potential for harm from opioids is great, and overdose-related deaths have continued to rise as these medications have become the epicenter of a crisis in the United States.

An opiate is a natural substance derived from the opium of a poppy plant. The term opioid, on the other hand, is a broad category referring to all natural, synthetic, and partly synthetic substances that interact with opioid receptors in the body and brain. Opioids typically act as full agonists to the mu-opioid receptor, resulting in an analgesic or sedative effect. These agents can also produce depressive effects on the central nervous system and the sensation of euphoria; the euphoric and sedative effects are driving forces behind misuse. Opioids include a wide spectrum of substances, from natural (morphine, codeine) to semisynthetic formulations (e.g., oxycodone and hydromorphone) and synthetic agents (e.g., fentanyl and methadone).

Opioid use disorder (OUD) describes a pattern of use leading to changes in behavior or distress. As with other substance use disorders, the DSM-5 diagnostic criteria require the presence of at least 2 of 11 specified symptoms or behaviors (see table of diagnostic criteria below) within a 12-month period.


Risk factors for the misuse of opioids include:

  • history of substance use disorder

  • severe or chronic pain syndromes

  • demographic vulnerability (e.g., unemployment or poverty)

  • comorbid mental disorders

Presenting symptoms associated with OUD include:

  • use of an opioid for longer than the intended treatment period

  • use in the absence of medical need

  • use of an excessive dose where a medical need does exist

  • planning of daily activities around acquisition of the opioid and its use

Screening tools:

  • Single-Question Drug Screen

    • How many times in the past year have you used an illegal drug or a prescription medication for nonmedical reasons? (A positive screen is 1 or more days.)

  • Two-Item Screen for Drug Use in Primary Care

    • Question 1: How many days in the past 12 months have you used drugs other than alcohol? (A positive screen is 7 or more days.) If fewer than 7, proceed with question 2.

    • Question 2: How many days in the past 12 months have you used drugs more than you meant to? (A positive screen is 2 or more days.)


The diagnosis of OUD involves identification of a pattern of use that is problematic and leads to clinically significant impairment or distress. In addition to meeting two or more DSM-5 criteria (which can include tolerance or withdrawal) within a 12-month period, diagnosis should involve a clinical history and physical examination.

DSM-5 Diagnostic Criteria for Opioid Use Disorder
If two or three items cluster together in the same 12 months, the disorder is mild; if four or five items cluster, the disorder is moderate; and if six or more items cluster, the disorder is severe.

  • Use of an opioid in increased amounts or longer than intended

  • Persistent wish or unsuccessful effort to cut down or control opioid use

  • Excessive time spent to obtain, use, or recover from opioid use

  • Strong desire or urge to use an opioid

  • Interference of opioid use with important obligations

  • Continued opioid use despite resulting interpersonal problems, social problems (e.g., interference with work), or both

  • Elimination or reduction of important activities because of opioid use

  • Use of an opioid in physically hazardous situations (e.g., while driving)

  • Continued opioid use despite resulting physical problems, psychological problems, or both

  • Need for increased doses of an opioid for effects, diminished effect per dose, or both

  • Withdrawal when dose of an opioid is decreased, use of drug to relieve withdrawal, or both

History and physical exam:

  • Obtain a personal history of comorbid mental health and medical conditions, including infectious diseases (HIV, tuberculosis, or hepatitis).

  • Assess for personal history of any substance use and gather details of social and family history.

  • Pay special attention to concomitant medical presentations such as pregnancy, other substance dependence (e.g., alcohol), and trauma-related injuries.

  • Conduct a mental status exam; patients may have slurred speech and impaired concentration.

  • Perform a full physical exam: Patients may present in a drowsy state with frequent nodding off although easily arousable; note signs of injection site marks, bruising, or scars on the extremities from intravenous substance use.

Common Signs of Opioid Intoxication and Withdrawal

Intoxication SignsWithdrawal Signs
Drooping eyelidsRestlessness, irritability, anxiety
Constricted pupilsInsomnia
Reduced respiratory rateYawning
Scratching (due to histamine release)Abdominal cramps, diarrhea, vomiting
Head noddingDilated pupils

Additional workup may include:

  • infectious screens (for HIV, hepatitis, tuberculosis)

  • complete blood count

  • liver function tests

  • urine screens (opioids are detectable in urine from 1 to 3 days after use; negative tests do not rule out use, disorder, or dependence)


Once assessment points to a diagnosis of opioid use disorder, severity should be assessed along with a review of comorbid conditions. It is important to take severity and comorbid conditions into account when evaluating the effect of opioids on the patient’s overall well-being and functionality.

  • A multimodal approach is important in the treatment of opioid addiction, including medication-assisted therapies and psychosocial behavior therapy.

  • Diagnosis and treatment planning with long-term management goals are the first step. Engaging patients or family in shared decision-making is important to success. This begins with sharing the diagnosis with the patient and discussing the treatment options and support mechanisms available.

Risk of overdose: The risk for overdose should be discussed early to educate patients and family or friends about overdose and possible interventions. If sobriety is desired, patient education is crucial given the risk of overdose after resuming illicit opioid use, due to loss of tolerance after a period of abstinence.

Factors that increase the risk of overdose include:

  • history of overdose

  • history of substance use disorder

  • high opioid dosages

  • simultaneous or concurrent benzodiazepine use

Treatment of overdose:Naloxone (Narcan), an opioid receptor antagonist, rapidly reverses the effects of opioid overdose. It restores breathing in a patient with life-threatening opioid-induced respiratory depression and is therefore important to immediate recovery or rescue following an overdose. The reversal effects of naloxone last for 30–90 minutes, the half-life of the drug, after which the effects of the overdose may return.

  • Naloxone can be administered as an injectable, auto injectable, or nasal spray. Police officers and first responders are routinely trained to administer naloxone; family members or friends can also be trained. (See How to Use the VA Intramuscular Naloxone Kit or Naloxone Nasal Spray.)

  • Although not considered a treatment for opioid use disorder, naloxone is included in some treatment formulations with buprenorphine. In some cases, it may be is co-prescribed with opioids when the risk of overdose is perceived to be high (e.g., patients prescribed more than 50 morphine milligram equivalents per day or patients with preexisting respiratory conditions such as chronic obstructive pulmonary disease or obstructive sleep apnea). 


Medication-assisted treatment (MAT): Opioid agonists are used to reduce or replace abused opioids, improve functionality and quality of life, and prevent overdose or death. Opioid addiction is difficult to reverse because it often causes permanent changes in the brain that create a need for a baseline level of opioid for normal day-to-day functioning that will not diminish with cessation. Medications used to treat OUD aim to reduce cravings and withdrawal symptoms and support the rewiring of brain circuits without creating a new dependence. Three MAT agents that are FDA approved for the treatment of opioid addiction are naltrexone (opioid antagonist), buprenorphine (partial opioid agonist), and methadone (opioid agonist). Buprenorphine and methadone provide basal opioid levels without euphoria or sedation.

  • Methadone is a long-acting, full opioid agonist (mu-receptor) that works by blunting opioid cravings and has been shown to reduce drug use and death from overdose. However, methadone is associated with a risk of dependence. It is administered via daily supervised administration in a clinic setting.

  • Buprenorphine is partial opioid agonist (mu-receptor) and a mixed opioid agonist–antagonist that allows for some stimulation of the opioid receptors but with tempered effect and less physiological dependence. Buprenorphine can be given in an office-based opioid treatment (OBOT) program on a weekly or monthly basis. Special training may be necessary for practitioners to prescribe buprenorphine for opioid addiction treatment. The combination of buprenorphine and the short-acting opioid antagonist naloxone (Suboxone) counteracts the effect of injection opioids. Buprenorphine can also be prescribed for pain management. See this resource to learn how buprenorphine prescribing differs for pain management versus OUD.

  • Naltrexone is a slow-acting opioid antagonist that binds to and blocks opioid receptors to reduce the euphoric and sedative effects of opioids. It is used to treat acute overdose or, after a period of abstinence, to prevent relapse. Naltrexone reduces cravings, prevents relapse after a period of abstinence, and facilitates patient participation in other recovery activities and interventions such as psychosocial and behavioral therapies. Some experts recommend observed dosing or extended-release injectable forms in patients with problems with adherence. Naltrexone is available in both pill and injectable forms. Some experts recommend observed dosing or extended-release injectable forms in patients with problems with adherence.

For an overview of the three medications, see this NEJM Knowledge+ learning resource.

Nonpharmacologic treatment

Success in treatment of OUD requires a multimodal and continuing care approach. Each patient’s individual needs should be considered regarding MAT treatment options, treatment setting (inpatient, outpatient, or office-based therapy), intensity, and adjunctive or alternative treatment.

Psychosocial therapies such as counseling, behavioral interventions, and the use of support groups are important adjuncts to pharmacologic treatment. The therapies increase individual understanding of opioid addiction and how it is treated.

For more information on treatment in special populations, see the American Society of Addiction Medicine’s National Practice Guideline.

Opioid Withdrawal

Withdrawal from any opioid, including heroin, resembles severe influenza and is usually accompanied by the following symptoms:

  • pupillary dilation

  • lacrimation

  • rhinorrhea

  • piloerection (“goosebumps”)

  • yawning

  • sneezing

  • anorexia

  • nausea/vomiting

  • diarrhea

The Clinical Opiate Withdrawal Scale (COWS) can be used to measure symptoms of opioid withdrawal.

Opioid withdrawal is extremely uncomfortable and distressing for the patient but is usually not life-threatening. In contrast, opioid intoxication is much more likely to be life-threatening, and both intoxication and withdrawal carry significant risks of death when combined with benzodiazepines or alcohol.

Treatment: The mainstay of treatment for opioid withdrawal syndromes is usually a long-acting opioid that relieves the major symptoms of withdrawal. Opioids such as methadone are oral drugs but require physicians within licensed addiction-treatment programs to administer them to patients. Another frequently used opioid is buprenorphine, which is combined with naloxone to prevent diversion and injection. Buprenorphine can be prescribed in-office by providers who have completed a specialized training course. Many people with opioid addiction remain on prescribed opioids for their lifetimes. While this may seem counterintuitive, the prescribed opioids prevent overdose death and improve functionality for those addicted to short-acting prescription opioids or illegal heroin.

Treatment for Symptoms of Opioid Withdrawal with Long-Acting Opioid Agonists

(Source: Treatment of Opioid-Use Disorders. N Engl J Med 2016.)

Nonopioid therapy can be used to help treat anxiety, insomnia, and other withdrawal symptoms. Some of these indications, such as the use of clonidine to control symptoms of autonomic overactivity, are off-label and not FDA approved.

Opioid-Free Treatment of Opioid Withdrawal

(Source: Treatment of Opioid-Use Disorders. N Engl J Med 2016.)

Maintenance therapy: To prevent relapse, a combination of rehabilitation, supportive systems, and pharmacotherapies is required. Maintenance therapy may involve use of one of three agents: naltrexone, methadone, or buprenorphine. Naltrexone, a mu-opioid receptor antagonist is used in patients who are fully abstinent. In patients who may not be able to discontinue opioids, treatment options include methadone or buprenorphine.

Medications for Rehabilitation from an Opioid-Use Disorder


(Source: Treatment of Opioid-Use Disorders. N Engl J Med 2016.)

Stimulant Intoxication and Withdrawal

Stimulant withdrawal is not life-threatening, although stimulant intoxication is. Stimulant intoxication can lead to seizures. The following table describes the onset, symptoms, and management of stimulant intoxication and withdrawal:

Management of Stimulant Intoxication and Withdrawal

 Stimulant IntoxicationStimulant Withdrawal
  • Rapid onset

  • Symptoms may develop within hours, peak within 1–2 days, and usually decrease within 2 weeks (subacute withdrawal may persist for up to 3 weeks)

  • Diaphoresis

  • Hypertension

  • Tachycardia

  • Agitation (may abruptly develop with extreme violence)

  • Psychosis

  • Mydriasis

  • Seizures

  • Dysrhythmia

  • Chest pain

  • Insomnia/hypersomnia

  • Appetite changes

  • Depression/irritability

  • Motor disturbances

  • Benzodiazepines (IV/IM lorazepam, diazepam)

  • Antipsychotics (IV/IM ziprasidone, droperidol, haloperidol; oral olanzapine)

  • Critical hypertension: nitroprusside, phentolamine

    • Avoid pure beta-blockers

  • Hyperthermia: benzodiazepines, cooling measures

    • Avoid antipyretics

  • Supportive care (fluids, food, rest, low-stimulation environment)

  • Supportive care (fluids, food, rest, low-stimulation environment)

  • Benzodiazepines

  • Antipsychotics (IV/IM ziprasidone, droperidol, haloperidol; oral olanzapine)

  • Antidepressants


Landmark clinical trials and other important studies


Siefried KJ et al. CNS Drugs 2020.


Cheng HY et al. BMJ 2020.

Evidence is lacking for appropriate interventions in primary care but evidence except for treatment with acamprosate.


Dutra L et al. Am J Psychiatry 2008.

This study examined effect sizes for various interventions of different substance use disorders.


Park TW et al. Addiction 2020.

This study examined associations among benzodiazepine prescription and fatal opioid overdose, nonfatal opioid overdose, all-cause mortality, and buprenorphine discontinuation.

Read the NEJM Journal Watch Summary


Krawczyk N et al. Addiction 2020.

This retrospective cohort study examined the effects of opioid agonist treatment on overdoe-related mortality during and after treatment.


Pennington DL et al. Drug Alcohol Depend 2020.

Topiramate treatment for 12 weeks appeared to reduce alcohol use and post-concussive symptoms.


Heikkinen M et al. Addiction 2021.

The nation‐wide, register‐based cohort study examined the effectiveness of pharmacological treatments in patients with alcohol use disorder


Trivedi MH et al. N Engl J Med 2021.

Among adults with methamphetamine use disorder, the response over a period of 12 weeks among participants who received extended-release injectable naltrexone plus oral extended-release bupropion was low but was higher than that among participants who received placebo.

Read the NEJM Journal Watch Summary


Larochelle MR et al. Ann Intern Med 2018.

This study examined whether the use of medications for opioid use disorder could reduce mortality after overdose.


Sullivan MA et al. Am J Psychiatry 2019.

This study compared the effectiveness of extended-release and oral naltrexone in the treatment of opioid use disorder.


Krupitsky E et al. Lancet 2011.

A randomized, double-blind, controlled trial of extended-release injectable naloxone for treatment of opioid dependence after detoxification


Anton RF et al. JAMA 2006.

A comparison of the efficacy of medication, behavioral therapies, and a combination of both in the treatment of alcohol dependence


Hjermø I et al. Dan Med Bull 2010.

This retrospective study showed that phenobarbital is a safe alternative to diazepam for treatment of DT.


Rayner SG et al. Ann Intensive Care 2012.

In this retrospective review of 20 ICU patients who received dexmedetomidine as an adjunct treatment for alcohol withdrawal, dexmedetomidine therapy was associated with reduced benzodiazepine dosing, decreased alcohol withdrawal scoring, and blunted hyperadrenergic cardiovascular response.


The best overviews of the literature on this topic


Hellem TL. J Subst Abuse Treat 2016.


Schuckit MA. N Engl J Med 2014.

A review article on the recognition, prevention, and management of delirium tremens


Schuckit MA. N Engl J Med 2016.

A review of the management of opioid use disorders both in the acute setting and through maintenance regimens


Edelman EJ and Fiellin DA. Ann Intern Med 2016.

This issue provides a clinical overview of alcohol use, focusing on health benefits, harms, prevention, screening, diagnosis, treatment, and practice improvement.


Pace CA and Samet JH. Ann Intern Med 2016.

This American College of Physicians review provides a clinical overview of substance use disorders, focusing on epidemiology, prevention, diagnosis, complications, and management.


Connor JP et al. Lancet 2016.

A review of the neurobiology and management of alcohol use disorders


Volkow ND et al. N Engl J Med 2016.

This article reviews scientific advances in the prevention and treatment of substance use disorder and related developments in public policy.

Anton RF. N Engl J Med 2008.


Amato L et al. Cochrane Database Syst Rev 2010.

A meta-analysis on the use of benzodiazepines for alcohol withdrawal: Overall, benzodiazepines were found to be protective against alcohol withdrawal symptoms but no definite conclusions could be drawn given the heterogeneity of trials included in the analysis.


Friedmann PD. N Engl J Med 2013.

This article reviews patterns of alcohol use in adults and methods for identifying people with alcohol-dependence issues.


The current guidelines from the major specialty associations in the field


American Society of Addiction Medicine 2020.


American Psychiatric Association 2022.


Reus VI et al. Am J Psychiatry 2018.

Read the NEJM Journal Watch Summary

Additional Resources

Videos, cases, and other links for more interactive learning


This review explains harm-reduction strategies for three groups of patients: those who have not received previous opioid therapy, those receiving long-term opioid therapy, and those with an opioid use disorder. The authors discuss both risk assessment and the current approach to the use of medications for opioid use disorder.


Alcohol use is common in patients with liver disease, but medications effective in alcohol-use disorder are used sparingly. Even patients with advanced liver disease should receive treatment for alcohol-use disorder.


A 36-year-old man was seen in the emergency department because of opioid overdose. The patient was found unresponsive and cyanotic in a park. Naloxone was administered and his mental status normalized, but hypoxemia persisted. A diagnosis and management decisions were made.


The National Institutes of Health will work with private partners to develop better overdose-reversal and prevention interventions; find new medications and technologies to treat opioid addiction; and find safe, effective, nonaddictive strategies to manage chronic pain.