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Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr David Harrington, our...

Statistical Review – Non-Inferiority Trials with Dr. David Harrington

Beyond Journal Club Podcast from Core IM

Does colonoscopy prevent colon cancer, and does it save lives? There has never been a randomized controlled trial on the effect of screening colonoscopies before the NordICC trial, even though screening colonoscopy is a guideline-based recommendation for everyone over age 45....

The NordICC Trial: Does invitation to screening colonoscopy save lives?

Should your patients be reaching for albuterol when their asthma flares up? Some of us may have been treating asthma exacerbations incorrectly for many years… What is the right approach? Tune in to the fifth episode of Beyond Journal Club, a...

The MANDALA Trial: What is the Best Rescue Medication for Asthma?

How do you counsel patients eligible for the RSV vaccines? What do the results of the RENOIR and AReSVi trials tell us and how do they compare? How should we interpret vaccine trials in the first place? Tune in to the...

The RENOIR and AReSVi Trials: RSV & What Makes Vaccine Trials Different?

In community-acquired pneumonia, can steroids improve mortality? Past studies of steroids in CAP have been conflicting, with some showing a mortality benefit and others showing no difference. How does the CAPE COD trial change how we think about patients hospitalized with...

The CAPE COD Trial: Do Steroids Have a Role in Community-Acquired Pneumonia?

What is the difference between semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro) in metabolic outcomes and mechanism? How did we find out diabetes medications can help with weight loss? SURMOUNT-1 asked the question, "Does tirzepatide, a once weekly injectable drug used...

The SURMOUNT-1 Trial: How Did Diabetes Medications Become Weight Loss Meds?

Does adding revascularization by percutaneous coronary intervention (PCI) to optimal medical therapy improve survival and heart failure hospitalizations in patients with severe ischemic left ventricular systolic dysfunction? Some evidence suggests that patients with low ejection fraction benefit from revascularization by PCI....

The REVIVED Trial: Does PCI Save Lives in Heart Failure and CAD?

NEJM Journal Watch Research Summaries

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Research summaries covering topics relevant to residents and trainees.

And vaccination against shingles was associated with lower subsequent risk for vascular dementia or Alzheimer disease.

Chronic Varicella-Zoster Virus Brain Infection Might Trigger Dementia

For the first time, a professional organization offers guidance for managing asymptomatic elevated BP in the hospital and at discharge.

Managing Elevated Blood Pressure in the Hospital

In an observational study, risk during 2 years was 35% lower in SGLT-2 inhibitor users than in DPP-4 inhibitor users.

SGLT-2 Inhibitors and Risk for Dementia in Patients with Type 2 Diabetes

Invasive and conservative strategies had similar outcomes in a randomized trial involving patients age 75 years or older with non–ST-segment elevation myocardial infarction.

For Older Adults with NSTEMI, Is Invasive Treatment Warranted?

“Neffy” is an option for people who are reluctant to use self-injectable epinephrine.

Newly Approved Intranasal Epinephrine

Relatively low-resource interventions improved pain modestly but durably.

Do Telehealth Mindfulness-Based Interventions Relieve Chronic Pain?

Patients with worse baseline pain experienced greater improvements in sleep.

Does Chronic Pain Affect the Efficacy of Cognitive-Behavioral Therapy for Insomnia?

More nursing home residents received antiplatelet medications than oral anticoagulants in this retrospective study.

Antithrombotic Prescribing in Nursing Home Residents with Atrial Fibrillation

A retrospective analysis supports this drug–drug interaction.

Do CYP2D6-Inhibiting Antidepressants Worsen Pain for Patients on CYP2D6-Metabolized Opioids?

Among other things, this Endocrine Society guideline has abandoned its previously recommended categories for vitamin D “deficiency” and “insufficiency.”

Vitamin D for Preventing Disease: A New Guideline

Incorporating risk scoring systems could lower use of unnecessary venous thromboembolism prophylaxis by one third.

Optimizing VTE Prophylaxis in Hospitalized Patients

Follow-up has improved since 2012, but substantial healthcare disparities exist, and some gaps have widened.

Rate of Ambulatory Follow-Up After Cardiovascular-Related Hospitalization

On average, predicted 10-year estimates for atherosclerotic CV disease are much lower with the new calculator.

How Do Cardiovascular Risk Estimates from the New PREVENT Calculator Compare with Older Estimates?

In an observational study, venous thromboembolism occurred less commonly with aspirin than with anticoagulants.

Use of Aspirin for VTE Prophylaxis After Total Knee Arthroplasty Is Increasing

Survey results suggest that many women might prefer to delay screening.

Mammography Preferences Among Women in Their 40s

At 8 months, outcomes with self-fit and audiologist-fit devices were similar.

Effectiveness of Over-the-Counter Self-Fit Hearing Aids

A randomized trial showed benefits for patients with or without diabetes or prior stroke.

Intensive BP Reduction for Preventing Major Adverse Cardiovascular Events

Apixaban might present less bleeding risk than rivaroxaban or warfarin.

Atrial Fibrillation and Cirrhosis: Which Anticoagulant?

This large cohort study showed no benefit, adding to mostly negative prior studies.

Does a Daily Multivitamin Provide a Mortality Benefit?

Another study documents higher prescribing of diuretics in patients who initiate gabapentin or pregabalin.

More Data on Gabapentinoid-Induced Edema

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Statistical Review – Non-Inferiority Trials with Dr. David Harrington

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