Learning Lab NEJM Quick Take Videos

Since its emergence in late 2019, the SARS-CoV-2 pandemic has caused high morbidity and mortality, and new variants are spreading rapidly. The need for a vaccine that allows simplified transport, storage, and use in a pandemic has been enormous. New research...

Radical surgery, the standard of care in muscle-invasive urothelial carcinoma, is performed with curative intent, but more than 50% of patients have lethal metastatic recurrence. Adjuvant chemotherapy may prolong disease-free survival, but no consensus regarding...

Aspirin is recommended in established atherosclerotic cardiovascular disease to lower the risk of adverse health outcomes. Yet findings from observational studies and post hoc analyses of trial data are discordant regarding the preferred dosage, and there are open...

Case reports of favorable outcomes with endovascular therapy in patients with stroke caused by basilar-artery occlusion have impeded recruitment in randomized, controlled trials. In a meta-analysis and in a prospective registry, the majority of patients underwent...

In 2006, the most recent year with available data, 667,000 U.S. children, mainly under 3 years of age, underwent tympanostomy-tube placement for recurrent acute otitis media. Previous trials, all conducted before the introduction of pneumococcal conjugate...

Highly potent regimens to treat tuberculosis could allow the treatment course to be shortened to less than the currently required 6 months, potentially improving adherence and reducing adverse drug effects and costs. New research findings are summarized in...

Postpartum hemorrhage is a leading cause of severe maternal complications and death worldwide. Small, single-center trials have shown significantly reduced blood loss with tranexamic acid in elective cesarean delivery, but because of methodologic...

Severe Covid-19 pneumonia occurs in approximately 15% of patients and is associated with high mortality. Case reports and observational studies have suggested that treatment with tocilizumab causes rapid fever reduction and reduces need for oxygen support. New...

Nonanastomotic biliary strictures are a major complication after liver transplantation, and ischemia–reperfusion injury is a key mechanism in their development. Although static cold preservation provides some protection against injury, preclinical studies have shown that...

Patients admitted to the ICU with acute hypoxemic respiratory failure often receive supplemental oxygen with a high FIO2, which results in a high PaO2 and may be associated with increased mortality. Guidelines give no recommended oxygenation targets for adults...

PH1 is a rare, progressive genetic disease with life-threatening clinical manifestations that are due to increased hepatic oxalate production. Patients commonly present in childhood, but in one registry, 43% of patients with PH1 already had ESKD at the time of diagnosis...

Esophageal cancer causes more than half a million deaths each year. Neoadjuvant chemoradiotherapy followed by surgery is a widely used standard of care in resectable, locally advanced esophageal or gastroesophageal junction cancer, but the risk of...

Although lifestyle interventions are the cornerstone of weight management, sustaining weight loss over the long term is challenging. Clinical guidelines suggest adjunctive pharmacotherapy, particularly for adults with obesity, but the use of available medications...

Gestational diabetes mellitus is one of the most common complications of pregnancy and carries a risk of adverse outcomes in both mothers and babies. Universal screening is recommended at 24 to 28 weeks of gestation, but there is no consensus on which of two...

Spinal muscular atrophy is a rare, progressive neuromuscular disease. Type 1 SMA is characterized by the inability to sit without support and by reduced life expectancy; most infants with type 1 SMA do not survive beyond 2 years of age. New research findings are...

Albumin infusions were first used in patients with cirrhosis more than 70 years ago; a low serum albumin level has been associated with an increased risk of death among patients with cirrhosis and infections, and albumin infusions have reduced systemic inflammation...

Among patients with Covid-19 admitted to hospitals in 2020, the case fatality rate was high, especially among those receiving invasive mechanical ventilation, and there was a critical need for medicines with efficacy in severe illness. Research findings on dexamethasone...

Patients with ANCA-associated vasculitis are at risk for life-threatening complications, organ damage, toxic effects from medications used to treat the disorder, and deterioration of health-related quality of life. Treatments that increase the likelihood of sustained...

SARS-CoV-2 infection produces detectable immune responses; however, the extent to which previously infected people are protected from a second infection is uncertain. Understanding whether postinfection immunity exists and how long it lasts has major implications for the...

Preliminary data indicated high efficacy of an mRNA-based vaccine developed in collaboration between Moderna and the NIAID. The vaccine has now been evaluated in an ongoing phase 3 randomized, controlled trial. New research findings are summarized in...

Without preventive treatment, AF will recur in 90% of patients. Guidelines recommend antiarrhythmic drugs, but these agents have limited efficacy and substantial side effects. Trials of early catheter ablation with radiofrequency energy have been inconclusive. New...

Although recently approved therapies have reduced transfusion requirements in β-thalassemia and the incidence of vaso-occlusive episodes in sickle cell disease, neither treatment addresses underlying causes or fully ameliorates disease...

Allogeneic hematopoietic stem-cell transplantation from a matched sibling donor is curative in more than 90% of patients with sickle cell disease, but there is often no available donor. Whether a gene-editing strategy for induction of HbF would reduce symptoms has not...

The defining characteristic of heart failure with a reduced ejection fraction is decreased systolic function, but no medication that directly enhances systolic function has been shown to improve outcomes. New research findings are summarized in a short video.

Acute GVHD is a major complication and cause of death after allogeneic hematopoietic stem-cell transplantation. Even with standard prophylaxis regimens, GVHD occurs in 34 to 51% of patients within 100 days after transplantation. New research findings are...

Several medical treatments for Parkinson’s disease are available, but refractory motor manifestations such as tremor and motor complications impair quality of life for many patients. Results from uncontrolled studies suggested that focused ultrasound...

Covid-19 has affected tens of millions of people globally since it was declared a pandemic by the WHO on March 11, 2020. Safe and effective vaccines are urgently needed. New research findings are summarized in a short video.

A recent phase 1 trial indicated that the Moderna mRNA-1273 vaccine had an acceptable safety profile and was immunogenic in participants younger than 55 years of age. The immune response to Covid-19 vaccine candidates in older populations is of paramount...

About 7% of U.S. adults receive a diagnosis of severe hypercholesterolemia (LDL cholesterol levels ≥190 mg/dl), and data from patients with heterozygous familial hypercholesterolemia indicate that the risk of coronary artery disease may be six times that in patients without...

Type 2 diabetes is the leading cause of chronic kidney disease worldwide. Guidelines for the management of CKD in patients with type 2 diabetes recommend control of hypertension and hyperglycemia, as well as the use of an ACE inhibitor or an ARB and, more recently...

Patients with type 2 diabetes would generally prefer fewer injections and greater flexibility than is typical of the current once-daily treatment options. Reducing the number of injections could increase adherence to insulin treatment, thereby potentially improving...

The ALK inhibitor crizotinib was shown to be superior to platinum-based chemotherapy as first-line therapy for NSCLC; subsequent trials showed that second-generation agents were superior to crizotinib. But despite improved efficacy, drug resistance and recurrent...

Although successful use of antibiotics for appendicitis was reported over 60 years ago, more than 95% of U.S. patients with appendicitis underwent appendectomy as recently as 2014, owing to insufficient data from randomized trials. New research findings are summarized...

Several agents have been evaluated for the treatment of Covid-19, but no antivirals have yet been shown to be efficacious. Remdesivir was identified as a possible therapeutic candidate owing to its ability to inhibit SARS-CoV-2 in vitro. New research findings...

About 30% of patients with non–small-cell lung cancer have resectable disease, but even with postoperative chemotherapy, disease recurrence or death within 5 years after surgery remains high (from 45% to 76%, depending on the stage of disease). New research...

In adults with Philadelphia chromosome–positive ALL, the use of ABL-specific TK inhibitors, with or without systemic chemotherapy, allows most patients to have a complete hematologic response; a sustained decrease in minimal residual disease is associated...

Obesity is associated with life-threatening diseases and premature death, and it can reduce life expectancy by 5 to 20 years. Bariatric surgery leads to durable weight loss and reduces cardiovascular risk, but the extent to which it increases the life span in patients with...

SGLT2 inhibitors reduce the risks of both hospitalization for heart failure and serious renal events in patients with type 2 diabetes. Since similar effects have not been seen with other antidiabetic drugs, these benefits cannot be explained by an action of SGLT2 inhibitors to...

Each year, about 5% of patients with atrial fibrillation have stroke, acute coronary syndrome, heart failure, or cardiovascular death, even with guidelinebased management, and 35 to 50% of patients receiving anticoagulation either undergo inpatient treatment...

Combination platinum-based chemotherapy is the standard first-line treatment for advanced urothelial carcinoma, but most patients have disease progression within 9 months; the median overall survival is 14 to 15 months with cisplatinbased regimens and 9 to 10...

Long-term oxygen therapy improves survival outcomes in patients with COPD, but those who have nocturnal arterial oxygen desaturation but not severe daytime hypoxemia do not currently qualify for such therapy. Whether providing oxygen at night would improve...

Patients with nonmetastatic, castration-resistant prostate cancer are at risk for progression to metastatic disease, which is often accompanied by the onset of cancer-related symptoms. Prolonging survival and delaying symptom onset while minimizing treatment-related...

Obesity is more common among Black and Hispanic adults, especially those with low income and limited education, than among White and Asian adults. Because intensive lifestyle intervention has not been fully adopted in primary care, the prevalence of obesity has...

The ADA-recommended glycated hemoglobin target (<7%) is attained by less than 20% of children with type 1 diabetes. A closed-loop system that automates insulin delivery in a glucose-responsive manner (an “artificial pancreas”) has the potential to improve...

Although studies have suggested that bariatric surgery improves metabolic function and that gastric bypass has unique benefits for glycemic control, the results from such studies are confounded by differences in weight loss among patients who undergo the...

Standard treatment for AML consists of intensive induction chemotherapy followed by consolidation chemotherapy, stem-cell transplantation, or both. Older patients may be ineligible for standard chemotherapy or have refractory disease; less intensive regimens...

Both chloroquine and the derivative molecule hydroxychloroquine have in vitro activity against SARS-CoV and SARS-CoV-2, but to date, no medication has been shown to prevent SARS-CoV-2 transmission. New research findings are summarized in a short video.

Respiratory syncytial virus, the most common cause of hospitalizations for respiratory illness among infants and young children, results in largely predictable annual epidemics worldwide and is a leading cause of infant deaths; preterm infants are at particularly high risk. New...

Households and other close-contact settings are important sites for transmission of influenza virus. Postexposure antiviral prophylaxis can reduce the risk among contacts but has been associated with rapid emergence of drug-resistant virus. New research findings are...

The risk of a subsequent stroke in the first few months after an acute ischemic stroke or TIA is about 5 to 10%. Aspirin has been used to reduce risk; trials of aspirin in combination with other agents have shown promise in some patients but not others. New research findings...

Atopic dermatitis is a chronic, relapsing disease; pruritus, a characteristic symptom, can cause an itch–scratch cycle that may induce mechanical damage to skin and enhance inflammatory reactions, worsening the pruritus and affecting quality of life. New research...

COPD treatment takes a stepwise approach, with agents added to control symptoms and reduce exacerbations. Triple therapy with an inhaled glucocorticoid, a LAMA, and a LABA has been shown to reduce exacerbations and improve lung function and quality of life, but...

In sub-Saharan Africa and India, the numbers of newborns with sickle cell anemia are projected to increase by 30% by 2050. Without newborn screening programs and appropriate care, an estimated 50 to 90% of these children will die before 5 years of...

Studies in animals have shown that ACE2 is used by coronaviruses as a functional receptor. ARBs and ACE inhibitors increase the expression of ACE2; a hypothesis that their use may modify susceptibility to infection with SARS-CoV-2 in humans has developed. New...

Acute hepatic porphyria is caused by defects in heme biosynthesis enzymes; the accumulation of neurotoxic heme intermediates causes injury to the nervous system and other organs. Attacks typically warrant urgent medical attention, and options for...

Metastatic, castration-resistant prostate cancer is associated with decreased overall survival, worsening quality of life, and increased health care–related costs, and bone metastases develop in about a third of patients within 2 years after diagnosis. New research findings...

Tumors in up to 30% of patients with metastatic castration-resistant prostate cancer harbor deleterious aberrations in genes involved in DNA repair; patients may have disease progression during treatment, and outcomes are poor. New research findings are...

Lower-extremity peripheral artery disease affects more than 200 million people worldwide. Patients who undergo peripheral revascularization are at high risk for subsequent complications; their risk for acute limb ischemia is about 4 times that in patients who...

Heart failure with a reduced ejection fraction imposes a substantial health care burden, and the prognosis is particularly poor among patients at risk for rehospitalization or urgent outpatient treatment despite medical therapy. New research findings are summarized...

Effective treatments for Covid-19 have not yet been identified, but earlier experience with SARS and MERS has led to trials of existing agents, including lopinavir, an HIV-1 aspartate protease inhibitor, and ritonavir, added to increase the half-life of lopinivir by inhibiting...

The first cases of pneumonia of unknown origin were identified in Wuhan, China, in early December 2019. Little was known about the characteristics or transmission of the pathogen, identified as a novel coronavirus. The authors’ analysis of the clinical characteristics of a...

Venous thromboembolism is a common cause of complications and death in patients with cancer, but the high risk of recurrent thromboembolism and bleeding in such patients makes anticoagulant treatment challenging. New research findings are summarized in a short...

Antipsychotic drugs have produced clinical benefit in psychosis, but D2- receptor–binding agents often have limited efficacy in treating blunted affect and cognitive impairment. Atypical antipsychotics were shown to have fewer side effects related to movement...

The goals of treating patients with stable coronary disease are to reduce risk of death and ischemic events and to improve quality of life, but trials of various strategies added to guideline-based medical therapy have failed to show improved outcomes. New research...

In-hospital mortality after acute upper GI bleeding has been estimated at 10%. Endoscopy, which allows identification of the source of bleeding, is recommended within 24 hours after consultation; whether earlier endoscopy would reduce mortality has not been known. New...

Among some patients with HIV-1 infection who have undergone multiple antiretroviral therapies, options for future treatment are limited, owing to multidrug resistance or safety concerns, and there is a pressing need for new classes of antiretroviral drugs with novel...

Trials involving patients with acute sciatica caused by lumbar disk herniation have shown a short-term benefit of surgery over conservative care, but outcomes are similar by 6 to 12 months. Whether surgery has greater benefit in persistent sciatica has not been known...

Providing supplemental oxygen in the ICU often exposes patients to a high Fio2 and a higher-than-normal Pao2, which have been associated with increased mortality and fewer ventilator-free days. Studies have suggested that establishing regimens for limiting...

The 12-core systematic biopsy is the most common method for initial diagnosis and grading of prostate cancer, but it is associated with substantial diagnostic inaccuracy that can result in overtreatment of patients with low-grade disease or undertreatment when aggressive...

Evidence from multiple trials indicates that transcatheter aortic-valve replacement is an alternative to surgery in symptomatic aortic stenosis, but data on long-term clinical outcomes, bioprosthetic-valve function, and quality of life are limited. New research...

Early testing for harmful substances in bronchoalveolar-lavage fluid from patients with lung injury associated with vaping showed the presence of vitamin E acetate. A subsequent analysis of samples from 51 patients with EVALI along with samples obtained from...

Despite dramatic therapeutic advances over the past 20 years, most patients with HER2-positive metastatic breast cancer ultimately die from their disease. Moreover, as therapies have improved, the incidence of brain metastases, for which effective treatment options...

Lung cancer causes more deaths than breast, colorectal, and cervical cancers combined, but because about 70% of patients have advanced disease at the time of diagnosis, only 15% of patients with lung cancer are still alive 5 years later. New research findings are...

The most common treatment for spontaneous pneumothorax is drainage, sometimes progressing to surgical intervention. An alternative approach, conservative management, may be associated with lower risk and a shorter hospital stay, but there is a lack of...

Neisseria meningitidis, a major cause of meningitis and septicemia throughout the world, is associated with considerable morbidity and mortality. Development of a vaccine against meningococcal group B, the cause of most childhood cases in...

CKD-associated pruritus affects more than 60% of hemodialysis patients, often with intense and generalized itching that is associated with poor sleep, depression, and risk of infection and death. There is currently no approved therapy in the United States or Europe, and...

Observational data suggest that subclinical leaflet thrombosis may occur with bioprosthetic valves and that the risk can be reversed by anticoagulation. Current guidelines, based mainly on expert consensus, recommend dual antiplatelet therapy early after TAVR, but...

Meta-analysis has shown that lowering LDL cholesterol reduces the risk of stroke. Current guidelines recommend “intense” statin therapy after ischemic stroke of atherosclerotic origin but do not stipulate a target LDL cholesterol level because of limited data. New research...

Experimental and clinical evidence indicates that inflammation plays an important role in atherosclerosis, but a safe, effective, and widely available antiinflammatory treatment to reduce the risk of atherosclerotic events in patients with coronary artery disease has been...

Up to 85% of patients with advanced ovarian cancer have disease recurrence after standard treatment with surgical cytoreduction and systemic platinum– taxane chemotherapy. The use of additional agents has been limited by safety concerns and insufficient data. New...

After the deadly 2013–2016 outbreak of Ebola virus disease in West Africa ended,the WHO initiated discussions focused on how to assess experimentaltherapeutics. The consensus was that the most promising ones should be studiedin an RCT, if possible, when a new outbreak occurred. In August 2018, a newoutbreak began in the DRC.

Patients with a hip fracture are at substantial risk for death, health complications, and reduced quality of life, but whether total hip arthroplasty is more likely to result in fewer reoperations and better hip function than hemiarthroplasty has not been known. New...

Women with extremely dense breast tissue have an increased risk of breast cancer, and their cancers are less likely to be detected on mammography. Whether such patients would benefit from a tailored screening strategy supplemented with more sensitive imaging has...

Large trials of inhibitors of sodium–glucose cotransporter 2 have shown that they reduce the risk of hospitalization for incident heart failure in patients with diabetes, but whether SGLT2 inhibitors would also benefit patients with established heart failure, with or without diabetes, has not been known. New research findings are summarized in a short video.

Eradication of smallpox has not eliminated the risk of accidental or intentional reintroduction of the variola virus, and although smallpox vaccination was highly successful, traditional vaccines had toxic effects that could be severe. New research findings are summarized in...

Concerns have been raised about the risk of neurodegenerative disease associated with participation in contact sports, but incidence data among former professional soccer players are limited. New research findings are summarized in a short video.

Despite advances in care, attaining good glycemic outcomes in patients with type 1 diabetes remains challenging. The use of a closed-loop system (an “artificial pancreas”) that automates aspects of insulin delivery offers the potential to achieve near-normal glycemia...

In patients with STEMI undergoing PCI, dual antiplatelet therapy is used to prevent recurrent thrombotic events. The more potent platelet inhibitors increase the risk of bleeding, but the effectiveness of less potent inhibitors may vary according to the patient’s genotype. New research findings are summarized in a short video.

Randomized trials have shown the superiority of prasugrel and ticagrelor over clopidogrel in patients with acute coronary syndromes. However, the relative safety and efficacy of prasugrel and ticagrelor in patients for whom invasive evaluation is planned are unclear. New research findings are summarized in a short video.

Patients with STEMI often have multivessel coronary artery disease, with additional lesions in locations separate from the lesion that caused the acute event. Whether to routinely revascularize the nonculprit lesions or to manage them with medical therapy alone is a common dilemma. New research findings are summarized in a short video.

Chronic spontaneous urticaria is a skin disorder characterized by hives, angioedema, or both in the absence of specific external stimuli. Evidence suggests that this condition has a long duration and can negatively affect quality of life. The pathogenesis is not fully clear, but it is known to involve autoimmune mechanisms in most patients. New...

Although epidemiologic studies involving U.S. patients with asthma show a greater burden in black patients than in whites, treatment recommendations are based on trials with few black participants. Furthermore, response to asthma pharmacotherapy can be affected by genetic variants that reflect diverse ancestries. New research...

Socioeconomically vulnerable populations have high mortality from cardiovascular disease. Hypertension and hypercholesterolemia are particularly common in these groups, but treatment rates are strikingly low. New research findings are summarized in a short video.

CKD affects about 10% of the population worldwide, including 120 million people in China. Anemia, a complication of CKD, is associated with an increased risk of complications and death, but among patients with CKD who are not undergoing dialysis, it remains undertreated. New research findings are summarized in a short video.

One hypothesis for the mechanism of depression implicates deficits in γ-aminobutyric acid (GABA) and downstream alterations in monoaminergic neurotransmission; this hypothesis is supported by evidence in patients with depression and in patients who have died by suicide. New research findings are summarized in a short video.

Although the first-line HIV treatment recommended by the WHO can be safely used in pregnancy and during treatment for TB, it has a low resistance barrier and toxic effects are common. Other agents with benefits over the standard regimen may also have adverse effects; data in low- and middle-income countries, patients with TB...

Although numerous studies have examined local and regional associations between short-term exposures to PM and mortality, the varied modeling approaches used and the potential effect of publication bias create challenges in comparing data and synthesizing effect estimates. New research findings are summarized in a short video.

Type 1 diabetes is one of the most common diseases of childhood, and shortened life expectancy is associated with diagnosis at an early age. In genetically susceptible persons, type 1 diabetes progresses through asymptomatic stages before overt hyperglycemia develops; whether early intervention might alter progression to clinical...

Sickle cell disease affects approximately 100,000 persons in the United States and reduces life expectancy by approximately 30 years. The disease is caused by a single amino acid substitution that results in the production of sickle hemoglobin, or HbS. HbS polymerizes when deoxygenated, resulting in red-cell sickling and membrane...

Severe anemia is a leading cause of hospital admission among children in subSaharan Africa, and mortality and readmission rates are high. WHO guidelines encourage restrictive transfusion, but the evidence is weak and adherence is poor. New research findings are summarized in a short video.

Venous thromboembolism is common after major trauma, and pulmonary embolism accounts for 12% of all deaths. Whether placement of a vena cava filter would benefit patients when prophylactic anticoagulation is contraindicated has been uncertain. New research findings are summarized in a short video.

Steep reductions in the incidence of HIV infection worldwide are needed to curb the HIV–AIDS epidemic. A universal testing and treatment strategy is a potential approach, yet previous trial results are inconsistent. New research findings are summarized in a short video.

Cluster headache is a disabling disorder that patients may describe as the worst pain they have ever known. Treatment is aimed at terminating attacks or reducing their frequency, but there are currently no approved preventive medications in the United States. New research findings are summarized in a short video.

Recent trials have shown longer progression-free and overall survival in patients with metastatic, castration-sensitive prostate cancer when androgen-deprivation therapy was combined with other agents, but existing combinations may be associated with adverse events and reduced quality of life. New research findings are summarized in a short...

Clinically unresponsive patients can have EEG or MRI evidence of brain activation in response to spoken commands, but the prevalence and prognostic relevance of cognitive–motor dissociation are not well understood. New research findings are summarized in a short video.

Results from trials and population-based studies indicate that most patients need at least two antihypertensive agents to reach even conservative blood pressure goals. But the combinations recommended for black patients differ across U.S. and European guidelines. New research findings are summarized in a short video.

The increasing prevalence of type 2 diabetes is the primary factor in a global increase in end-stage kidney disease. Secondary and exploratory analyses have suggested that SGLT2 inhibition might improve renal outcomes; however, some uncertainty persists. New research findings are summarized in a short video.

Studies have suggested that improving glucose control in patients with diabetes improves cardiovascular outcomes; whether long-term follow-up of such patients would show a reduced incidence of cardiovascular events, lower mortality, or improved quality of life has been uncertain. New research findings are summarized in a short video.

Chronic lymphocytic leukemia is the most common leukemia in the United States. Ibrutinib and venetoclax monotherapies have produced favorable response rates, and preclinical models have indicated that the two drugs combined may be synergistic. New research findings are summarized in a short video.

Research published in 2008 indicated a mortality benefit when patients with ARDS received early muscular paralysis, but whether this benefit is evident with current ICU care has not been known. New research findings are summarized in a short video.

About 1.5 million patients receive cardiac implantable electronic devices worldwide every year. Despite the use of antibiotic prophylaxis and best surgical practices, infections after placement of these devices remain a major complication. New research findings are summarized in a short video.

The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited to within 4.5 hours after the onset of symptoms. Some trials have suggested that the treatment window may be extended in patients with ischemic but not yet infarcted brain tissue on imaging. New research findings are summarized in a short video.

Although advances in the treatment of multiple myeloma have prolonged survival, almost all patients eventually have a relapse. CAR T-cell therapy has emerged as a novel treatment that has the potential for long-term disease control in some hematologic cancers. New research findings are summarized in a short video.

Each year, about 1000 U.S. patients die while waiting for heart or lung transplantation. Although organ donation has increased by 20% during the past 5 years — largely because of deaths from drug overdose — many otherwise suitable organs have not been used because of donors’ HCV infection. New research findings are summarized in a short video.

Patients with recent-onset, symptomatic atrial fibrillation commonly undergo immediate restoration of sinus rhythm by means of pharmacologic or electrical cardioversion. Whether this is necessary is unclear, however, since AF often terminates spontaneously. New research findings are summarized in a short video.

Catheter ablation is recommended for drug-refractory atrial fibrillation. Radiofrequency ablation makes limited use of fluoroscopy, but it requires specialized training. Cryoablation, which requires more fluoroscopic guidance, is simpler, but is it safe and effective? New research findings are summarized in a short video.

Indwelling urinary catheters are commonly used in hospitals and can lead to preventable catheter-associated UTI. How can rates of catheter-associated UTI be reduced in hospitals?

Severe hemophilia A is often treated with infusions of factor VIII. But the infusions are burdensome, and antibodies develop in about 30% of patients. Would emicizumab, which mimics the function of factor VIII, reduce these problems?

These investigators analyzed consultations from five major airlines to a physician-directed communications center to study the epidemiology of 11,920 in-flight medical emergencies.

This trial assessed the efficacy and safety of radium-223 as compared with placebo in men with castration-resistant prostate cancer and bone metastases, a frequent and serious complication of prostate cancer.

Using data from two large screening trials, the authors identified factors associated with malignancy on follow-up of nodules first found on low-dose CT screening for lung cancer.

Twin birth is associated with a higher risk of adverse perinatal outcomes than singleton birth. This international trial compared planned vaginal birth and planned cesarean section in 2804 women carrying twins.

This study found an association between nut consumption and reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus, in two large cohorts of health professionals.

In a study of novice and experienced drivers, the authors found significant associations between secondary tasks (e.g., cell-phone dialing) and the risk of a crash or near-crash, particularly among novice drivers.

As the incidence of malaria diminishes, a better understanding of nonmalarial fever is important for effective management of illness in children. This study explores the spectrum of causes of fever in African children.

The current guidelines for recommended salt intake and the risks of cardiovascular disease and death related to salt consumption are described in a short animation.

LCZ696 was compared with enalapril in patients with advanced heart failure. LCZ696 was superior to enalapril in all outcomes, as summarized in this video.

Your 17-year-old patient tells you she’s terrified of becoming pregnant. How can you help her?

Patients who had received a drug-eluting stent and then dual antiplatelet therapy for 12 months were randomly assigned to 18 more months of therapy or aspirin alone. Continued therapy resulted in lower rates of stent thrombosis and major adverse cardiovascular events but more bleeding.

In this trial involving smokers who called the New Zealand national quitline, cytisine was superior to nicotine-replacement therapy in helping smokers quit.

In patients with acute ischemic stroke due to a proximal intracranial arterial occlusion, intraarterial treatment within 6 hours improved functional outcome at 90 days.

This study assessed prevention strategies in young women in South Africa, Uganda, and Zimbabwe using oral or vaginal antiretroviral agents. No approach was found to be effective.

A community-wide treatment program for yaws in Papua New Guinea, in which a single dose of azithromycin was administered, showed substantial disease control.

This study assessed children 4 to 11 months of age who were at high risk for development of peanut allergy. Peanut allergy was more than five times as likely to develop in children assigned to peanut avoidance.

Air pollution in southern California has been decreasing for several decades. How has this affected lung function in children?

Current treatments for Crohn’s disease, a chronic inflammatory illness, can increase the risk of infection and cancer and are ineffective in a third of patients. Is there anything more promising on the horizon?

The composite of death, myocardial infarction, or target-vessel revascularization occurred more frequently in patients treated with PCI with everolimus-eluting stents for multivessel coronary artery disease.

How does the duration of red-cell storage affect outcomes in patients undergoing cardiac surgery?

Alcoholic hepatitis can develop in patients with a history of heavy alcohol use, and mortality is high. Pentoxifylline and prednisolone are two commonly recommended treatments. Which treatment is more effective?

In patients with complicated intraabdominal infection, is a short, fixed-duration course of antibiotics as effective as a course that continues through the resolution of fever and other abnormalities?

Telomeres shorten with DNA replication, and shorter telomeres are linked to disease. Androgenic hormones regulate expression of the telomerase gene. Would treatment with synthetic androgen slow the shortening of telomeres?

In a randomized trial, financial incentives were more effective than usual care in achieving smoking cessation.

For young women, attending university means confronting the risk of sexual assault. Are there effective interventions?

Treatment with statins reduces LDL cholesterol and lowers the risk of cardiovascular events. Would the addition of ezetimibe further improve outcomes with statins after acute coronary syndromes?

Is there an effective medical treatment to combat obesity? New research findings on liraglutide, a glucagon-like peptide-1 analogue approved for the treatment of type 2 diabetes.

In this study, kidneys from deceased donors who were randomly assigned to receive mild hypothermia showed a lower frequency of delayed graft function.

Venous thromboembolism is sometimes the first sign of cancer. But how often is that so?

Patients with atrial fibrillation are at increased risk of stroke. Warfarin anticoagulation is often used to reduce risk, but it is usually stopped perioperatively. Temporary “bridging” with heparin is common, but is it necessary?

Neonatal jaundice is a common threat to newborns worldwide. Expensive phototherapy equipment is impractical in developing countries. Is sunlight an effective alternative?

Thousands of couples struggle with unexplained infertility. The typical approach to treatment begins with ovarian stimulation. Which agent is most effective for this purpose?

If the nicotine content of cigarettes were lower, would smokers consume more cigarettes per day, or fewer?

Remote ischemic preconditioning has been reported to reduce biomarkers of ischemia and reperfusion injury in patients who undergo cardiac surgery. But does it really improve clinical outcomes?

Hypoglycemia is common in neonates; in severe cases, it can cause neurologic impairment. But how low is too low?

Is the benefit of TKR worth the postoperative pain and possible long-term complications?

Genetic testing is not currently part of the treatment algorithm for prostate cancer. But could DNA-repair defects influence the response to prostate cancer treatment?

Can malignant transformation of parasite cells cause neoplasms in an immunosuppressed host?

PCI is known to relieve angina in patients with stable ischemic heart disease, but does it prolong survival?

Reduced leaflet motion was detected on computed tomography in 22 patients in a clinical trial of transcatheter aortic-valve replacement (TAVR) and in 17 patients in two registries. The condition resolved with anticoagulation.

For blood-pressure control, is intensive or standard treatment more effective at reducing the rate of cardiovascular events in high-risk patients?

Daily use of preventive ART by gay and bisexual men has been shown to reduce the risk of acquiring HIV, but adherence has been a challenge. Would starting prophylaxis when sexual activity begins reduce risk?

Scabies affects as many as a hundred million people worldwide and can lead to serious complications. In areas where scabies is endemic, would mass administration of anti-scabies drugs reduce prevalence?

Andexanet, a small-molecule factor Xa fragment, rapidly reversed the anticoagulant activity of rivaroxaban and apixaban in older healthy volunteers.

Smokers are at high risk for COPD, but some smokers with COPD symptoms do not meet the diagnostic criteria for COPD. How often do smokers with normal lung-function results have severe respiratory exacerbations?

Although treatments for Hodgkin’s lymphoma have a high cure rate, survivors are at a substantial risk of secondary cancers. Have changes in treatment implemented since the 1980s reduced this excess risk?

Chronic hepatitis C virus infection causes progressive liver fibrosis, which can lead to cirrhosis and hepatocellular carcinoma. Is there an effective oral regimen?

Allogeneic hematopoietic stem-cell transplantation is used to treat leukemia and other bone marrow disorders, but chronic GVHD is a leading cause of late morbidity and mortality. Would a modified regimen decrease GVHD without increasing infections and relapses?

Up to a third of patients with tuberculous meningitis die despite treatment. Standard treatment is based on data for pulmonary TB but may not achieve sufficient drug concentrations in CSF. Would a modified regimen improve outcomes?

Immunosuppressive therapy in patients with kidney transplants has reduced the incidence of allograft rejection, but standard therapy may not adequately preserve allograft function. Would a different regimen improve outcomes?

Testosterone levels in men decrease with age, contributing to a decline in physical mobility, sexual function, and energy. Would treatment with testosterone be beneficial for older men?

The usefulness of adjuvant chemotherapy after surgery for stage II colon cancer is unclear; many patients are treated to benefit a few. Are there biomarkers that might indicate which patients are at greatest risk of relapse?

In 1999, the WHO recommended routine antibiotics for children with severe acute malnutrition, which is often complicated by bacterial infection. Is such treatment beneficial?

Acquired thrombotic thrombocytopenic purpura is a microvascular thrombosis with high morbidity and mortality. Is there a way to improve outcomes?

ACGME work-hour policies were created to minimize long shifts for residents and reduce potential harm to patients. Do the policies affect patient outcomes or residents’ learning experience?

The risk of stillbirth is higher among older pregnant women. Would induction of labor to reduce the risk of stillbirth increase the risk of cesarean delivery?

Malaria infection during pregnancy may increase the risk of fetal loss and maternal death. Data on artemisinin-based therapy in pregnant women are limited. Are such therapies efficacious and safe for pregnant women?

In this trial, withholding parenteral nutrition from critically ill children was clinically superior to providing early parenteral nutrition.

Previous studies showed that introducing peanuts to infants at high risk for allergy reduces the incidence of allergy. But does early introduction of other allergenic foods have a similar effect?

Transcatheter aortic-valve replacement is a less invasive alternative to open surgery for high-risk patients with severe aortic stenosis. Could TAVR criteria be expanded to include patients at low or intermediate risk?

The elevated risk of stroke or acute coronary syndrome after a transient ischemic attack can be estimated with a scoring system in which a high score indicates the need for urgent evaluation. Has this approach led to a reduction in risk? 

Spinal stenosis can cause back and leg pain and severely impair quality of life. Decompressive laminectomy relieves pressure on spinal nerve roots but can cause instability. Does spinal fusion performed along with decompression surgery improve outcomes? 

Gliomas are a heterogeneous group of tumors that arise from the glia, the supporting cells of the CNS. Previousevidence has shown that chemotherapy added to radiation can prolong progression-free survival. 

Pregnant women with a short cervix have an increased risk of premature delivery. Placement of a cervical pessary has been used to help prevent this, but evidence supporting the effectiveness of this approach has been mixed. 

Lyme disease is a tickborne illness that can cause persistent arthralgia, fatigue, and neurologic and cognitive disturbances despite appropriate initial treatment with antibiotics. Would longer-term treatment improve outcomes? 

Despite advances in resuscitation and intensive care management, outcomes after cardiac arrest remain poor, and in patients without ST-segment elevation, the role of immediate coronary angiography is a matter of debate. New research findings are summarized in a short video.

Factor Xa inhibitors used to treat and prevent thrombotic events may cause or worsen acute major bleeding. New data suggest that bleeding episodes associated with factor Xa inhibitors may be treatable using a specific reversal agent. Research findings are summarized in a short video.

MDR tuberculosis is considerably more difficult to treat than drug-susceptible TB, especially in resource-poor settings. Is there a way to achieve treatment success more easily than the course recommended in the 2011 WHO guidelines? New research findings are summarized in a short video.

Acute pulmonary embolism is a leading cause of maternal death in the Western world. But routine diagnostic use of CT pulmonary angiography or ventilation– perfusion scanning exposes both mother and fetus to radiation. New research findings are summarized in a short video.

Surgery to remove retained products of conception is one of the most common gynecologic operations performed worldwide. Pelvic infection is a serious potential consequence of such surgery, particularly in low-income countries. New research findings are summarized in a short video.

Cross-sectional studies from Ebola outbreaks suggest that patients who survive EVD can have myriad health complications. New research findings are summarized in a short video.

Some retrospective analyses have suggested a potential survival benefit from systematic pelvic and paraaortic lymphadenectomy in patients with macroscopically completely resected advanced ovarian cancer. New research findings are summarized in a short video.

Although parenteral thromboprophylaxis can reduce the risk of venous thromboembolism in patients undergoing chemotherapy, the absolute risk reduction is modest, there is a risk of major bleeding, the cost is high, and daily injections are required. New research findings are summarized in a short video.

Patients with early breast cancer who are found to have residual invasive disease after neoadjuvant chemotherapy plus HER2-targeted therapy have a greater risk of recurrence or death than patients with a pathological complete response. New research findings are summarized in a short video.

Community-acquired pneumonia is the most common infection leading to hospitalization and death in all age groups, especially the elderly. For pathogens such as Streptococcus pneumoniae and Haemophilus influenzae, resistance to existing antibiotic agents has increased. New research findings are summarized in a short video.

Patients with infective endocarditis typically receive antibiotics intravenously for up to 6 weeks; in those who survive the initial phase, the main reason to stay in the hospital is to complete the intravenous treatment. New research findings are summarized in a short video.

In thrombotic thrombocytopenic purpura, autoantibodies inhibit activity of the von Willebrand factor–cleaving protease ADAMTS13, which leads to platelet consumption in VWF–platelet aggregates and microvascular thrombosis. The ensuing tissue ischemia and multiorgan dysfunction may result in thromboembolic events and death. New...

Latent, undetectable Plasmodium vivax hypnozoites can cause multiple clinical relapses, which can increase the disease burden and impede efforts to eliminate malaria. Treatment with primaquine for 14 days is effective, but adherence is a problem. New research findings are summarized in a short video.

Sickle cell anemia is associated with acute and chronic complications that lead to poor quality of life and early death. Hydroxyurea is an effective treatment, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. New research findings are summarized in a short video

Patients with hypertriglyceridemia remain at substantial cardiovascular risk despite the use of statins. Medications that reduce triglyceride levels, such as extended-release niacin and fibrates, have not reduced cardiovascular event rates in such patients. New research findings are summarized in a short video.

Although the majority of patients with newly diagnosed advanced ovarian cancer have no evidence of disease after standard treatment with surgery and platinumbased chemotherapy, about 70% have a relapse within the subsequent 3 years. New research findings are summarized in a short video.

Bisphosphonates have been shown to prevent fractures in women with postmenopausal osteoporosis. But since most fractures in postmenopausal women occur in those with osteopenia, therapies that are effective in such women are needed. New research findings are summarized in a short video.

In patients with heart failure, medical therapy and cardiac resynchronization may provide symptomatic relief and, in some patients, lessen the severity of secondary mitral regurgitation, but whether correcting mitral regurgitation improves prognosis is unknown. New research findings are summarized in a short video.

Despite response rates of 60 to 65% with standard first-line treatment for extensive-stage small-cell lung cancer, outcomes remain poor, with a median overall survival of about 10 months. New research findings are summarized in a short video.

Despite the availability of evidence-based treatments, patients who have had an acute coronary syndrome remain at high risk for recurrent ischemic cardiovascular events. New research findings are summarized in a short video.

Gastroenteritis accounts for 1.7 million ED visits among U.S. children every year; health care providers have had little to offer as treatment. Several guidelines now recommend probiotics, a growing multibillion-dollar industry. New research findings are summarized in a short video.

Minimally invasive surgery was adopted as an alternative to open surgery for radical hysterectomy in patients with early-stage cervical cancer before highquality evidence regarding its effect on survival was available. New research findings are summarized in a short video.

Despite the widespread use of immunomodulatory agents and proteasome inhibitors, relapsed or refractory multiple myeloma is common, and once the disease becomes refractory to these drugs, the prognosis is poor. New research findings are summarized in a short video.

Anti-CD20 antibodies such as rituximab are integral components of treatment for non-Hodgkin’s lymphoma, but once the lymphomas become refractory to standard therapies, the prognosis is poor. New research findings are summarized in a short video.

Tuberculosis is the leading infectious cause of death worldwide. An effective vaccine for persons with latent infection could interrupt transmission and have a marked effect on tuberculosis control. New research findings are summarized in a short video.

The benefit of aspirin for patients with cardiovascular disease is well established, but whether there is a preventive benefit — especially in patients with diabetes, who are at substantial risk — has not been clear. New research findings are summarized in a short video.

Acute kidney injury, the most frequent complication in septic shock, is associated with high mortality. Renal-replacement therapy is the standard of care, but when to initiate treatment is controversial. New research findings are summarized in a short video.

Studies to predict the development of obesity on the basis of childhood BMI have suggested a correlation, but most have evaluated outcomes at a young age or have had a short observation period or a small sample size. New research findings are summarized in a short video.

The incidence of sudden cardiac death is high during the early months after an MI. Whether the wearable cardioverter–defibrillator can protect against sudden death during this high-risk period is unclear. New research findings are summarized in a short video.

Diarrhea-related deaths in children are largely preventable, but the development of targeted approaches to reducing deaths from diarrhea in Africa has been hampered by inadequate prevalence and incidence data. New research findings are summarized in a short video.

MS typically appears in young adulthood, but 3% to 5% of cases have an onset in early childhood or adolescence. No disease-modifying therapies have FDA approval for persons younger than 18 years of age. New research findings are summarized in a short video.

Effective antivirals are needed for the treatment and prevention of influenza virus infections, but circulating influenza viruses are increasingly resistant to the antiviral agents currently in use. New research findings are summarized in a short video.

Current treatment for severe hemophilia A requires more than two infusions of factor VIII every week, a substantial treatment burden that affects adherence. New research findings are summarized in a short video.

Postpartum hemorrhage is the most common cause of maternal death. Oxytocin, the standard preventive therapy, requires cold storage, which is not available in many countries. New research findings are summarized in a short video.

Intravenous thrombolysis with alteplase is standard treatment within 4.5 hours after the onset of acute ischemic stroke, but in many cases, the time at onset is unknown. New research findings are summarized in a short video.

For women who remain pregnant beyond 39 weeks, common clinical practice has been based largely on observational studies comparing labor induction with spontaneous labor. New research findings are summarized in a short video.

Isoniazid is the recommended treatment for latent tuberculosis infection, but its benefit is substantially reduced because of hepatotoxicity and poor rates of regimen completion. New research findings are summarized in a short video.

Hereditary angioedema is characterized by recurrent episodes of swelling that can be life-threatening. New research findings are summarized in a short video.

Acute pain crises reduce quality of life and increase the risk of death in patients with sickle cell disease. Treatment with l-glutamine may lower the incidence of pain crises. New research findings are summarized in a short video.

A genetic assay predicts a benefit of chemotherapy if the score is high and a low risk of recurrence without chemotherapy if it is low, but the benefit of chemotherapy for those with a midrange score is unknown. New research findings are summarized in a short video.

Smallpox was declared eradicated in 1980, but variola virus, which causes smallpox, still exists, and there is no known effective treatment. New research findings are summarized in a short video.

Despite treatment, approximately 20% of patients with asthma have uncontrolled, moderate-to-severe disease, with substantially reduced lung function and the risk of further loss of function over time. New research findings are summarized in a short video.

Cisplatin is part of standard therapy for hepatoblastoma, a rare liver cancer, but hearing loss is a serious and permanent side effect. New research findings are summarized in a short video.

Many treatment protocols for diabetic ketoacidosis in children advocate slow rehydration to prevent brain injury, but whether the speed of administration of intravenous fluids influences outcomes remains unclear. New research findings are summarized in a short video.

Medical management of early pregnancy loss with prostaglandin analogues allows for planned, expedited expulsion of the nonviable tissue, but the rate of failure of this strategy diminishes its clinical usefulness. New research findings are summarized in a short video.

Observational studies have suggested that endovenous treatment of varicose veins — which may be particularly appropriate for the elderly population with venous leg ulcers — may improve ulcer healing. New research findings are summarized in a short video.

Conventional therapy for X-linked hypophosphatemia is associated with incomplete healing of rickets, skeletal deformity, persistent short stature, gastrointestinal side effects, and metabolic and endocrine abnormalities. New research findings are summarized in a short video.

Patients with mild asthma often use low-dose inhaled glucocorticoid maintenance therapy and β2 -agonists for symptom relief, but poor adherence to maintenance treatment is a major problem. New research findings are summarized in a short video.

Given the severe clinical consequences of ZIKV infection, large numbers of asymptomatic travelers, and reports of transmission through transfusion, would screening of donated blood be a cost-effective way to minimize risk? New research findings are summarized in a short video.

Studies have shown that triple inhaled therapy has benefits in patients at risk for frequent or severe exacerbations, but the therapy has required the use of multiple inhalers several times a day. New research findings are summarized in a short video.

Would mass distribution of a broad-spectrum antibiotic agent reduce childhood mortality in sub-Saharan Africa? New research findings are summarized in a short video.

The current standard of care for patients with β-thalassemia — lifelong, regular red-cell transfusions and iron chelation — is associated with a risk of serious complications. New research findings are summarized in a short video.

Prevention of metastases to bones and other sites is a key treatment goal in prostate cancer, but resistance to standard therapy develops in almost all men with the disease. New research findings are summarized in a short video.

Approximately 75% of patients with advanced renal-cell carcinoma have an intermediate or poor prognosis, with a low rate of response to standard treatment with sunitinib and a high rate of toxic effects. New research findings are summarized in a short video.

Six months of chemotherapy with oxaliplatin plus a fluoropyrimidine is standard in stage III colon cancer, but oxaliplatin is associated with cumulative neurotoxicity. Would a shorter course be effective? New research findings are summarized in a short video.

Helicobacter pylori infection is a major cause of gastric cancer, but whether patients with early disease undergoing endoscopic resection would benefit from H. pylori eradication therapy has been unknown. New research findings are summarized in a short video.

Since the emergence of the Zika epidemic in 2015, infection during pregnancy has been shown to cause severe birth defects, with risk estimates ranging from 6% to 42%. New research findings are summarized in a short video.

Early signs of loss of asthma control can signal an impending exacerbation. Escalation of treatment has been considered as a way to prevent full-blown exacerbations, but evidence to support this approach is limited. New research findings are summarized in a short video.

Intravenous administration of isotonic crystalloid fluids is one of the most common medical therapies, but whether the composition of the fluid has an effect on outcomes has not been known. New research findings are summarized in a short video.

Direct oral anticoagulants are commonly used for extended prophylaxis against venous thromboembolism after total hip or knee arthroplasty. Trials and metaanalyses have suggested that aspirin may be equally effective. New research findings are summarized in a short video.

Daily injection with low-molecular-weight heparin is the recommended treatment for cancer-associated venous thromboembolism; the safety and efficacy of direct oral anticoagulants have not been established. New research findings are summarized in a short video.

In previously treated patients with multiple myeloma, daratumumab added to standard therapy has prolonged progression free-survival, but its efficacy in newly diagnosed myeloma has been unknown. New research findings are summarized in a short video.

Chronic kidney disease and ESRD are increasing in prevalence worldwide, but the long-term outcomes of childhood kidney diseases remain largely unknown. New research findings are summarized in a short video.

Several studies have advanced the hypothesis that influenza may trigger acute cardiovascular events, but most were underpowered or limited by inaccurate diagnostic methods or had designs that were susceptible to bias. New research findings are summarized in a short video.

Household contacts of persons with active tuberculosis are at increased risk for contracting the disease, but a lack of high-quality evidence for screening contacts has been a barrier to widespread implementation. New research findings are summarized in a short video.

Median progression-free survival in patients with advanced non–small-cell lung cancer treated with EGFR tyrosine kinase inhibitors is 11 months. Is there a more efficacious treatment? New research findings are summarized in a short video.

Trials have shown that endovascular thrombectomy within 6 hours after the onset of ischemic stroke symptoms has a clinical benefit, but the effect after more than 6 hours is not known. New research findings are summarized in a short video.

Prophylactic treatment of severe hemophilia A with factor VIII can necessitate frequent infusions that may fail to achieve adequate hemostasis to prevent breakthrough bleeding and that affect quality of life. New research findings are summarized in a short video.

In sub-Saharan Africa, a large number of infants are affected by hydrocephalus that develops after neonatal ventriculitis and is often associated with poor developmental outcomes. New research findings are summarized in a short video.

The global incidence of diabetes is rising, and in most patients with type 1 diabetes, insulin therapy alone is not sufficient to achieve adequate glycemic control. New research findings are summarized in a short video.

For patients with hemophilia, the goal is to develop a therapeutic intervention that can achieve sustained clotting factor levels that are adequate to prevent bleeding, without the need for further treatment. New research findings are summarized in a short video.

Patients with chronic migraine have functional impairment and reduced quality of life. Preventive treatment is recommended but may be underused or ineffective. New research findings are summarized in a short video.

Persons with high levels of circulating Loa loa microfilariae may have serious adverse events, including death, after mass administration of ivermectin. 

Most patients with stage III, locally advanced, unresectable non–small-cell lung cancer have disease progression despite chemotherapy with concurrent radiation.

The incidence of cutaneous melanoma has continued to increase in recent years; patients with stage III disease are at risk of post-resection recurrence and death from metastatic melanoma.

SMA is a progressive motor neuron disease with an onset during infancy that results in failure to meet motor milestones and in death or the need for mechanical ventilation by 2 years of age. 

Current treatment guidelines for COPD recommend triple therapy with inhaled glucocorticoids, long-acting β2 agonists, and long-acting muscarinic-receptor antagonists, but 30 to 40% of patients continue to have moderate or severe exacerbations. 

Triple therapy (oral anticoagulation plus two antiplatelet agents) is the standard of care after PCI in patients with atrial fibrillation, but it is associated with a high risk of major bleeding.

Fragility fractures are common in postmenopausal women with osteoporosis; treatment has focused on increasing bone formation and decreasing bone resorption to reduce risk.

Most patients with follicular lymphoma will eventually have a relapse, and early progression is associated with shorter survival. Is there a safe and effective way to prolong progression-free survival?

Supplemental oxygen has been routinely recommended for patients with suspected acute MI, but too much oxygen may contribute to reperfusion injury. Is routine use of oxygen warranted?

Canakinumab targets a proinflammatory cytokine implicated in the development of atherothrombotic plaques. Whether reducing inflammation without lowering cholesterol would prevent cardiovascular events is unclear.

The global emergence of antibiotic-resistant TB has led to increased transmission of disease. Prompt point-of-care testing to determine the most effective treatment is needed. New research findings are summarized in a short video. 

Measles–mumps–rubella vaccination typically consists of two doses administered in childhood, but mumps outbreaks among young adults continue to occur. New research findings are summarized in a short video.

Treatment of hemophilia A, an inherited bleeding disorder, includes infusions that may result in the development of antibodies that can inhibit efficacy and increase morbidity. New research findings are summarized in a short video.

The prevalence of rheumatic heart disease has declined worldwide during recent decades, especially in higher-income countries. What is the current global burden? New research findings are summarized in a short video.

Preterm preeclampsia is an important cause of maternal and perinatal death and complications. Low-dose aspirin has been recommended for pregnant women considered to be at high risk. New research findings are summarized in a short video.

Measurement of circulating DNA has been studied as a way to find residual disease in cancer patients. But can cell-free DNA be used to screen asymptomatic persons? New research findings are summarized in a short video.

Vasodilatory shock is a life-threatening syndrome that requires immediate treatment; conventional vasopressors have a narrow therapeutic window and toxicities at high doses. New research findings are summarized in a short video.

Giant-cell arteritis causes headaches, vision loss, jaw claudication, and stroke, and it often relapses as glucocorticoids are tapered. New research findings are summarized in a short video.

The protein angiopoietin-like 3 is an experimental target for therapy to reduce lipid levels and cardiovascular disease risk. New research findings are summarized in a short video.

Clonal hematopoiesis of indeterminate potential (or CHIP) increases mortality and coronary heart disease. Could CHIP also cause atherosclerosis? New research findings are summarized in a short video.

Obesity and overweight are increasing in prevalence, but the overall effect on global health has been uncertain. New research findings are summarized in a short video.

The EPA sets air-quality standards to protect the health of the U.S. population. Are current standards stringent enough? New research findings are summarized in a short video.

Small, nonrandomized studies have shown that body positioning after an acute stroke may affect outcomes. New research findings are summarized in a short video.

Babies who were exposed to opioids in utero are at risk for neonatal abstinence syndrome. New research findings are summarized in a short video.

Although completion lymph-node dissection has been recommended in patients with melanoma and sentinel node metastases, its effect on survival has been unclear. New research findings are summarized in a short video.

Patients who have had a first clinical demyelinating event have a high rate of conversion to MS. Is there a way to prevent or delay onset? New research findings are summarized in a short video.

Low cardiac output syndrome is a common complication of cardiac surgery and is associated with increased mortality. Levosimendan has been shown in small studies to be an effective therapy.

Does exercise improve physical function in obese older adults? New research findings are summarized in a short video.

In patients with coronary artery disease undergoing PCI, hyperemic agents such as adenosine, used to reduce distal microvascular resistance, may have side effects. New research findings are summarized in a short video.

Little is known about long-term outcomes after bystander CPR and defibrillation in cases of out-of-hospital cardiac arrest. New research findings are summarized in a short video.

Catheter ablation is an invasive procedure; patients usually receive periprocedural anticoagulants for several weeks. New research findings are summarized in a short video.

Ustekinumab, which targets a subunit of IL-23, has shown efficacy and safety in patients with psoriasis. But is there a more effective IL-23 inhibitor? New research findings are summarized in a short video.

Large infrastructure disruptions during major marathons are likely to affect the delivery of medical care to nonparticipants who live near marathon routes, but data on the effects have been lacking. New research findings are summarized in a short video.

Studies have shown the importance of intensive glucose lowering, blood-pressure control, and use of statins to reduce cardiovascular risk and mortality in patients with diabetes, but long-term trends in such patients are unknown. New research findings are summarized in a short video.

In patients with severe, symptomatic aortic stenosis, transcatheter aortic-valve replacement has become the preferred therapy for patients at high surgical risk; efficacy and safety in lower-risk patients are unclear. New research findings are summarized in a short video.

HPV causes genital warts and cervical and other anogenital cancers. The HPV vaccine is recommended for girls and women 9 to 26 years of age to reduce infections, but information on safety in pregnant women is limited. New research findings are summarized in a short video.

Sub-Saharan Africa has the highest rate of death associated with rotavirus. Current oral rotavirus vaccines require refrigeration, which makes transportation and storage challenging. Is there a low-cost, heat-stable alternative? New research findings are summarized in a short video.

Urothelial carcinomas affect parts of the urinary system. The prognosis for advanced disease is poor, and after failure of first-line platinum-based combination chemotherapy, treatment options are limited. Is there an effective second-line therapy? New research findings are summarized in a short video.

Chronic myeloid leukemia, a myeloproliferative neoplasm, is associated with the Philadelphia chromosome. Imatinib targets the product of the chromosome, but little has been known about long-term safety and efficacy.

Subclinical hypothyroidism or hypothyroxinemia during pregnancy may be associated with impaired cognitive function in offspring. Do screening and treatment improve outcomes? New research findings are summarized in a short video.

Patients with hereditary angioedema with C1 inhibitor deficiency may have recurrent, unpredictable swelling episodes that require immediate treatment, but current options are limited by side effects. Is there a safe and effective therapy? New research findings are summarized in a short video.

EGFR tyrosine kinase inhibitors are standard treatment for non–small-cell lung cancer. Despite high tumor response rates, disease progresses in most patients after 9 to 13 months. Is there a way to lengthen progression free survival? New research findings are summarized in a short video.

Patients who undergo arthroscopic knee surgery and lower-leg casting are thought to be at increased risk for venous thromboembolism, but the benefits and risks of preventive anticoagulation are not clear. New research findings are summarized in a short video.

Patients with sickle cell disease may experience pain crises related to P-selectin, which contributes to vaso-occlusion. Would an antibody that blocks binding to P-selectin reduce the frequency of pain crises? New research findings are summarized in a short video.

Clostridium difficile is a common cause of infectious diarrhea in hospitalized patients; recurrent infection can be difficult to treat and may lead to rehospitalization. Is there an agent to prevent recurrence?

In July 2016, emergency services in Brooklyn responded to a scene of mass intoxication of 33 persons who had been exposed to an “herbal incense” product. How was the cause of their zombielike behavior identified?

More than 6 million U.S. children and adolescents have migraine headaches, but there is little evidence to support any specific therapy for prevention. Are the most commonly used medications beneficial or harmful?

High LDL cholesterol is a major risk factor for cardiovascular disease. Reducing circulating PCSK9 levels with PCSK9 antibodies has been shown to reduce LDL cholesterol but has a short duration of effect. Is there a longer-acting agent? .

NSAIDS such as ibuprofen and naproxen can provide pain relief but may increase the risk of GI bleeding. Previous studies showed that high doses of celecoxib increased cardiovascular harm, but the safety of modest doses was unclear.

Acute otitis media is the most common indication for which U.S. children receive antibiotics, usually for 10 days. Given growing concern about antimicrobial resistance, can treatment duration be shortened without changing outcomes?

In pregnant women, acute Zika virus infection has been associated with fetal death and fetal brain defects. What is the extent of abnormal CNS findings in affected infants during the first months of life?

Babesia microti causes babesiosis, an infection that can be severe in some patients. Transmission occurs primarily by tick bites, but infections from blood transfusion may be underestimated. Would effective screening of donated blood reduce risk?

Rates of new HIV infection in women are high in sub-Saharan Africa. Antiretroviral pills and gels have not lowered rates, possibly owing to low adherence. Would a monthly vaginal ring inserted by women themselves reduce new infections?

Patients with brainstem strokes or degenerative disorders such as ALS may have normal cognition without the ability to move or speak. Could a brain–computer interface enable autonomous communication?

Blockade of the ER signaling pathway is a common therapeutic strategy in advanced breast cancer, but resistance may occur. Palbociclib appears to be safe in combination with endocrine therapy such as letrozole; does the combination improve outcomes?

The FDA requires manufacturers to assess the cardiovascular risk of all new therapies for type 2 diabetes.Semaglutide, a glucagon like peptide-1 analogue, lowers blood glucose, but does it increase cardiovascular risk?

Antiretroviral medications are used to prevent perinatal transmission of HIV from a mother to her baby, but doesthe benefit outweigh the potential toxicity and adverse pregnancy outcomes associated with such therapy?

In patients with COPD and severe resting hypoxemia, long-term use of supplemental oxygen outside the hospitalis known to reduce mortality. Does long-term oxygen also benefit COPD patients with less severe hypoxemia?

Syncope is the transient loss of consciousness due to cerebral hypoperfusion. Various conditions can lead to syncope, including pulmonary embolism. How common is pulmonary embolism in patients with syncope?

PSA testing often detects localized prostate cancers that progress slowly. Current management can includesurveillance, surgery, or radiotherapy. Which approach is associated with better outcomes and fewer side effects?

Although endemic transmission of measles was declared eliminated in the United States in 2000, outbreaks still occur, especially in clusters of unvaccinated persons, as a result of travel. What are the features of such an outbreak?

The risk of infection with cesarean delivery is 5 to 10 times that with vaginal delivery, even with a cephalosporingiven before incision. Ureaplasma organisms are thought to be the culprit. Would addition of azithromycin reducerisk?

Intracranial pressure after traumatic brain injury can be lowered with medical treatment or with decompressivecraniectomy, but whether craniectomy helps patients with persistently elevated pressure despite medical treatment is unclear.

Herpes zoster can severely impact quality of life, and the risk increases with age. A previous study showed that a subunit vaccine significantly reduced risk in adults 50 or older. How efficacious is it in those 70 or older?

Patients with acute leukemia or myelodysplastic syndrome may need hematopoietic-cell transplants. HLA-identicalsiblings are often unavailable as donors. Can umbilical-cord blood from an unrelated donor be used successfully?

An interim analysis showed that early initiation of antiretroviral therapy achieved a 96% reduction in the incidence of HIV-1 infection in serodiscordant couples. Is the protection offered by ART durable in such couples?

Medications reduce symptoms of essential tremor in some patients, but in others the symptoms are debilitating.Neurosurgery targeting the thalamus can effectively suppress tremor; could focused ultrasound provide anoninvasive alternative?

Observational studies have suggested an association between the use of acetaminophen and asthma exacerbations in children, but the association has not been rigorously examined. Is ibuprofen a better choice?

For decades, thymectomy has been a mainstay in the treatment of myasthenia gravis, but there has been no rigorous evidence of its benefit. Does thymectomy improve clinical outcomes?

The U.S. Amish and Hutterite populations share a common ancestry, and both live in farming communities, yet asthma is four times as common among the Hutterites. Can farming techniques and exposure to animals explain the difference?

Liraglutide lowers blood glucose and is associated with weight loss, lowered BP, and an increase in heart rate.Would treatment with liraglutide have a beneficial effect on cardiovascular outcomes in patients with diabetes?

International travel can be fun and exciting, but over 25% of travelers report an illness during their trip. Pretravel health consultation with a physician is advised, but what should the consultation look like?

Recurrent ventricular tachycardia is associated with high mortality and morbidity. An ICD can be effective, but theshocks are painful and upsetting. Antiarrhythmic drugs and catheter ablation can suppress tachycardia; whichstrategy is better?

Ticagrelor is an antiplatelet therapy that is an alternative to aspirin for preventing recurrent stroke. Does ticagrelor produce better outcomes than aspirin?

Evidence is emerging that the efficacy of malaria vaccination can wane over time, resulting in an eventual rebound in malaria cases. Is this “age shift” true in the case of the RTS,S/AS01 malaria vaccine?

Patients with advanced Hodgkin’s are often treated with one of two chemotherapy regimens associated with similar survival but different toxicities. Could escalating or de-escalating therapy according to interim PET findingsimprove outcomes?

Taenia solium infects humans who have eaten contaminated pork. Larvae migrate to tissues, which can lead to neurocysticercosis, a major cause of seizures in developing countries. Can transmission be stopped on a population level?