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Exploring controversies in clinical research
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Clinical Spotlight
A New Approach for Treating Patients with Intermittent Mild Asthma
International guidelines recommend as-needed inhaled steroids for mild asthma.
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Clinical Spotlight
Estrogen-Progestin Therapy Elevates Risk for Breast Cancer — Should This Influence Clinical Practice?
No; benefits will outweigh risks for many menopausal patients who, through discussion of research findings and shared decision making, can make informed choices about HT use.
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Clinical Spotlight
Unraveling the Safety Profile of Proton-Pump Inhibitors
A large randomized trial has shown no association between PPI use and most of the adverse outcomes noted in observational studies.
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Clinical Spotlight
How Should We Use Conjugate Pneumococcal Vaccine in Immunocompetent Older Adults?
An expert panel no longer recommends it for everyone: Now clinicians and patients will have to decide on their own.
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Clinical Spotlight
Risk Stratification and D-Dimer Can Safely Exclude Pulmonary Embolism in Pregnant Patients
Several recent studies provide evidence that these tools can be used to avoid imaging in many pregnant patients with suspected PE.
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Clinical Spotlight
Preparing Children for Travel: When to Vaccinate Outside Traditional Endorsed Schedules
New recommendations for travel vaccines for young children may be confusing for practitioners, but resources are available to help.
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Clinical Spotlight
Adverse Effects of Fluoroquinolones: Where Do We Stand?
The FDA recently issued a new warning on aortic rupture; how should this affect practice?
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Clinical Spotlight
New Indication for Rivaroxaban: What Are the Tradeoffs?
This drug now is approved to lower cardiovascular risk in selected high-risk patients with atherosclerosis, but potential benefits and harms should be weighed carefully.
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Clinical Spotlight
Aspirin for Primary Prevention of Cardiovascular Events
Two new studies push the pendulum away from aspirin prophylaxis.
