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Exploring controversies in clinical research
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Clinical Spotlight
The Aducanumab Controversy – How Do Clinicians Proceed?
Aducanumab has been FDA-approved for mild cognitive impairment and mild dementia due to Alzheimer disease despite controversy over the research findings to date. Careful consideration of appropriate use is needed.
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Clinical Spotlight
One-Step or Two-Step Test for Diagnosing Gestational Diabetes?
The one-step test results in higher utilization of healthcare resources but similar pregnancy outcomes.
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Clinical Spotlight
How Should We Advise Our Immunocompromised Patients After COVID-19 Vaccination?
Several recent cohort studies provide some guidance.
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Clinical Spotlight
Chloroquine and Hydroxychloroquine: Old Drugs in a New COVID-19 World
Absent quality data, the use of these drugs in management of COVID-19 should be reserved for clinical trials.
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Clinical Spotlight
ACE Inhibitors and ARBs During the COVID-19 Pandemic
How should clinicians navigate clinical uncertainty for patients who are taking angiotensin-converting–enzyme inhibitors or angiotensin-receptor blockers?
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Clinical Spotlight
Thrombolysis for Acute Ischemic Stroke in the Extended Time Window?
New AHA/ASA guidelines based on recent trials give moderate support for treatment of selected late-presenting patients.
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Clinical Spotlight
Sulfonylureas for Patients with Type 2 Diabetes: Still an Option
Glimepiride, in particular, does not appear to confer excess risk for adverse cardiovascular outcomes.
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Clinical Spotlight
Left Main Coronary Artery Disease: PCI vs. CABG
New data bring new controversy.
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Clinical Spotlight
A New Approach for Treating Patients with Intermittent Mild Asthma
International guidelines recommend as-needed inhaled steroids for mild asthma.
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Clinical Spotlight
Estrogen-Progestin Therapy Elevates Risk for Breast Cancer — Should This Influence Clinical Practice?
No; benefits will outweigh risks for many menopausal patients who, through discussion of research findings and shared decision making, can make informed choices about HT use.
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Clinical Spotlight
Unraveling the Safety Profile of Proton-Pump Inhibitors
A large randomized trial has shown no association between PPI use and most of the adverse outcomes noted in observational studies.
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Clinical Spotlight
How Should We Use Conjugate Pneumococcal Vaccine in Immunocompetent Older Adults?
An expert panel no longer recommends it for everyone: Now clinicians and patients will have to decide on their own.
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Clinical Spotlight
Risk Stratification and D-Dimer Can Safely Exclude Pulmonary Embolism in Pregnant Patients
Several recent studies provide evidence that these tools can be used to avoid imaging in many pregnant patients with suspected PE.
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Clinical Spotlight
Preparing Children for Travel: When to Vaccinate Outside Traditional Endorsed Schedules
New recommendations for travel vaccines for young children may be confusing for practitioners, but resources are available to help.
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Clinical Spotlight
Adverse Effects of Fluoroquinolones: Where Do We Stand?
The FDA recently issued a new warning on aortic rupture; how should this affect practice?
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Clinical Spotlight
New Indication for Rivaroxaban: What Are the Tradeoffs?
This drug now is approved to lower cardiovascular risk in selected high-risk patients with atherosclerosis, but potential benefits and harms should be weighed carefully.
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Clinical Spotlight
Aspirin for Primary Prevention of Cardiovascular Events
Two new studies push the pendulum away from aspirin prophylaxis.
