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This interactive feature describes a 40-year-old man who presented to the ED with a 5-day history of worsening sore throat, diffuse muscle aches, joint pains, and fevers with temperatures of up to 38.9°C. Test your diagnostic and therapeutic skills at NEJM.org. ...

A 40-year-old Man with a a 5-Day History of Worsening Sore Throat, Diffuse Muscle Aches, Joint Pains, and Fevers with Temperatures of up to 38.9°C

This interactive feature describes a 66-year-old man who presented to the ED with 3 days of progressively worsening chest discomfort. Test your diagnostic and therapeutic skills at NEJM.org.

A 66-year-old Man with 3 Days of Progressively Worsening Chest Discomfort

This interactive feature describes a 44-year-old woman with sickle cell disease who presented to the emergency department with pain throughout her body. She was found to be positive for severe acute respiratory syndrome coronavirus 2. Test your diagnostic and therapeutic skills...

A 44-year-old Woman with Sickle Cell Disease and Pain Throughout Her Body

This interactive feature describes a 36-year-old man with HIV infection who presented to the hospital with fever and a mass on the left side of the neck. Test your diagnostic and therapeutic skills at NEJM.org.

A 36-year-old Man with HIV Infection, Fever, and a Mass on the Left Side of the Neck

This interactive feature describes a 59-year-old man who presented to the hospital with crampy abdominal pain on the left side, irritability, and confusion that had begun 2 days before the current presentation. Test your diagnostic and therapeutic skills at NEJM.org. ...

A 59-year-old Man with Crampy Abdominal Pain, Irritability, and Confusion

A 68-year-old man presented to his primary care doctor with blurry vision in his right eye. Test your diagnostic and therapeutic skills at NEJM.org.

A 68-year-old Man with Blurry Vision in His Right Eye

A 50-year-old woman presented to the ED with pleuritic chest pain and shortness of breath. Test your diagnostic and therapeutic skills at NEJM.org.

Thinking Outside the Heart

This interactive feature describes a 70-year-old Albanian woman with progressive pain in the right upper quadrant. She described it as a dull ache that radiated to her midback and lower abdomen. She also noted fevers, anorexia, and fatigue. Test your skills at...

A 70-Year-Old Albanian Woman With Progressive Pain in the Right Upper Quadrant

This interactive feature describes a 68-year-old woman with a 2-year history of intermittent palpitations who is admitted to the cardiac care unit for management of ventricular tachycardia. She states that the palpitations have been occurring with increasing frequency and that she now also has...

A 68-year-old Woman with a 2-Year History of Intermittent Palpitations

This interactive case describes a 59-year-old man who presented to the ED with worsening fatigue and headache. While describing his symptoms, he became unable to produce fluent speech. Test your diagnostic and therapeutic skills at NEJM.org.

A 59-year-old Man with Worsening Fatigue and Headache

Beyond Journal Club Podcast from Core IM

Does colonoscopy prevent colon cancer, and does it save lives? There has never been a randomized controlled trial on the effect of screening colonoscopies before the NordICC trial, even though screening colonoscopy is a guideline-based recommendation for everyone over age 45....

The NordICC Trial: Does invitation to screening colonoscopy save lives?

Should your patients be reaching for albuterol when their asthma flares up? Some of us may have been treating asthma exacerbations incorrectly for many years… What is the right approach? Tune in to the fifth episode of Beyond Journal Club, a...

The MANDALA Trial: What is the Best Rescue Medication for Asthma?

How do you counsel patients eligible for the RSV vaccines? What do the results of the RENOIR and AReSVi trials tell us and how do they compare? How should we interpret vaccine trials in the first place? Tune in to the...

The RENOIR and AReSVi Trials: RSV & What Makes Vaccine Trials Different?

In community-acquired pneumonia, can steroids improve mortality? Past studies of steroids in CAP have been conflicting, with some showing a mortality benefit and others showing no difference. How does the CAPE COD trial change how we think about patients hospitalized with...

The CAPE COD Trial: Do Steroids Have a Role in Community-Acquired Pneumonia?

What is the difference between semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro) in metabolic outcomes and mechanism? How did we find out diabetes medications can help with weight loss? SURMOUNT-1 asked the question, "Does tirzepatide, a once weekly injectable drug used...

The SURMOUNT-1 Trial: How Did Diabetes Medications Become Weight Loss Meds?

Does adding revascularization by percutaneous coronary intervention (PCI) to optimal medical therapy improve survival and heart failure hospitalizations in patients with severe ischemic left ventricular systolic dysfunction? Some evidence suggests that patients with low ejection fraction benefit from revascularization by PCI....

The REVIVED Trial: Does PCI Save Lives in Heart Failure and CAD?

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Interactive Medical Cases

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