A Man with Seizures and Agitation

A Man with Seizures and Agitation

A 41-year-old man with epilepsy presented with increased seizure activity. In the hospital, the patient struck a staff member and said, “I thought they were trying to kill me.” A diagnosis was made. ...

Degenerative Rotator-Cuff Disorders

Degenerative Rotator-Cuff Disorders

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical therapy, is typically recommended; surgery is considered in some cases.

Candida auris Infections

Candida auris Infections

C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health care facilities. ...

A Girl with Abdominal Pain

A Girl with Abdominal Pain

A 16-year-old girl was admitted to the hospital because of abdominal pain, nausea, and vomiting. Abdominal tenderness and guarding with palpation were present. A diagnosis was made.

Lung Transplantation

Lung Transplantation

Lung transplantation has evolved from an experimental to a standard treatment. The authors review recent developments and future opportunities in the delivery of this potentially life-transforming therapy.

A Newborn with Hypoxemia and a Lung Opacity

A Newborn with Hypoxemia and a Lung Opacity

A full-term infant was admitted to the neonatal intensive care unit for hypoxemic respiratory failure. During the third week, a chest radiograph showed a persistent opacity in the left lower lobe. A diagnosis was made. ...

Two Sides to the Story

Two Sides to the Story

A 51-year-old man presented with 1 week of nonproductive cough and dyspnea that limited his ability to climb stairs, previously done with ease. He reported no fever, chest pain, rhinorrhea, or sore throat. ...

Uterine Fibroids

Uterine Fibroids

Uterine fibroids, a frequent cause of heavy bleeding and anemia, are common. Hysterectomy is the most common treatment, but safer options, such as localized ablation and oral GnRH antagonist therapies, are underused. ...

Lead Poisoning

Lead Poisoning

Chronic lead poisoning, even at low levels, is a risk factor for cardiovascular disease in adults and cognitive deficits in children. The authors review the effects of chronic, low-level lead poisoning. ...

Semaglutide in Obesity and Knee Osteoarthritis

Semaglutide in Obesity and Knee Osteoarthritis

Among participants with obesity and pain related to knee osteoarthritis, treatment with weekly semaglutide for 68 weeks resulted in greater reductions in body weight and knee pain than placebo.

Evaluating new trials and their place in the literature

Research summaries covering topics relevant to residents and trainees.