The NordICC Trial: Does invitation to screening colonoscopy save lives?

The NordICC Trial: Does invitation to screening colonoscopy save lives?

Does colonoscopy prevent colon cancer, and does it save lives? There has never been a randomized controlled trial on the effect of screening colonoscopies before the NordICC trial, even though screening colonoscopy is a guideline-based recommendation for everyone over age 45....

The MANDALA Trial: What is the Best Rescue Medication for Asthma?

The MANDALA Trial: What is the Best Rescue Medication for Asthma?

Should your patients be reaching for albuterol when their asthma flares up? Some of us may have been treating asthma exacerbations incorrectly for many years… What is the right approach? Tune in to the fifth episode of Beyond Journal Club, a...

The RENOIR and AReSVi Trials: RSV & What Makes Vaccine Trials Different?

The RENOIR and AReSVi Trials: RSV & What Makes Vaccine Trials Different?

How do you counsel patients eligible for the RSV vaccines? What do the results of the RENOIR and AReSVi trials tell us and how do they compare? How should we interpret vaccine trials in the first place? Tune in to the...

The CAPE COD Trial: Do Steroids Have a Role in Community-Acquired Pneumonia?

The CAPE COD Trial: Do Steroids Have a Role in Community-Acquired Pneumonia?

In community-acquired pneumonia, can steroids improve mortality? Past studies of steroids in CAP have been conflicting, with some showing a mortality benefit and others showing no difference. How does the CAPE COD trial change how we think about patients hospitalized with...

The SURMOUNT-1 Trial: How Did Diabetes Medications Become Weight Loss Meds?

The SURMOUNT-1 Trial: How Did Diabetes Medications Become Weight Loss Meds?

What is the difference between semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro) in metabolic outcomes and mechanism? How did we find out diabetes medications can help with weight loss? SURMOUNT-1 asked the question, "Does tirzepatide, a once weekly injectable drug used...

The REVIVED Trial: Does PCI Save Lives in Heart Failure and CAD?

The REVIVED Trial: Does PCI Save Lives in Heart Failure and CAD?

Does adding revascularization by percutaneous coronary intervention (PCI) to optimal medical therapy improve survival and heart failure hospitalizations in patients with severe ischemic left ventricular systolic dysfunction? Some evidence suggests that patients with low ejection fraction benefit from revascularization by PCI....

Research summaries covering topics relevant to residents and trainees.